HuLPr00032

Uniprot ID

1C01_HUMAN

Uniprot Acc

P30499;O02865;O19676;P30500;Q29986;Q9UQS9;

Protein name

HLA class I histocompatibility antigen, Cw-1 alpha chain

Comment

FUNCTION:Involved in the presentation of foreign antigens to the immune system.||SUBUNIT:Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||PTM:Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).||POLYMORPHISM:The following alleles of Cw-1 are known:Cw*01:01 (Cw1.1), Cw*01:02 (Cw1.2), Cw*01:03 and Cw*01:04. The sequence shown is that of Cw*01:01.||SIMILARITY:Belongs to the MHC class I family.||SIMILARITY:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

major histocompatibility complex, class I, C

Protein sequence

MRVMEPRTLILLLSGALALTETWACSHSMKYFFTSVSRPG RGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQE GPEYWDRETQKYNRQAQTDRVSLRNLRGYYNQSEAGSHT LQWMCGCDLGPDGRLLRGYDQYAYDGKDYIALNEDLRSW TAADTAAQITQRKWEAAREAEERRAYLEGTCVEWLRRYL ENGKESLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPA EITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVMVP SGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVA GLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSN SAQGSDESLIASKA

Database cross reference

RefSeq Protein accession:NP_002108
RefSeq Protein gi:52630342

GO:0005887;C:integral to plasma membrane;NAS:UniProtKB. GO:0042612;C:MHC class I protein complex;IEA:UniProtKB-KW.

GO-F

GO:0032393;F:MHC class I receptor activity;NAS:UniProtKB.

GO-P

GO:0002474;P:antigen processing and presentation of peptide antigen via MHC class I;IEA:UniProtKB-KW. GO:0006955;P:immune response;NAS:UniProtKB. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW.