HuLPr00039

Uniprot ID

1C16_HUMAN

Uniprot Acc

Q29960;O78091;O78202;Q29862;Q29959;Q9MY74;Q9MYI3;Q9TNZ8;

Protein name

HLA class I histocompatibility antigen, Cw-16 alpha chain

Comment

FUNCTION:Involved in the presentation of foreign antigens to the immune system (By similarity).||SUBUNIT:Heterodimer of an alpha chain and a beta chain (beta-2- microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).||SUBCELLULAR LOCATION:Isoform 1:Cell membrane; Single-pass type I membrane protein.||SUBCELLULAR LOCATION:Isoform 2:Secreted.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q29960-1; Sequence=Displayed; Name=2; IsoId=Q29960-2; Sequence=VSP 008096;||PTM:Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).||POLYMORPHISM:The following alleles of Cw-16 are known:Cw*16:01, Cw*16:02 (CW*CL10V) and Cw*16:04. The sequence shown is that of Cw*16:01.||SIMILARITY:Belongs to the MHC class I family.||SIMILARITY:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Subcellular localization

Isoform 1:Cell membrane;Single-pass type I membrane protein.

Gene name

major histocompatibility complex, class I, C

Protein sequence

MRVMAPRTLILLLSGALALTETWACSHSMRYFYTAVSRPG RGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQE GPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHT LQWMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEHLRSC TAADTAAQITQRKWEAARAAEQQRAYLEGTCVEWLRRYL ENGKETLQRAEHPKTHVTHHLVSDHEATLRCWALGFYPA EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP SGEEQRYTCHVQHEGLPEPLTLRWEPSSQPTIPIVGIVA GLAVLAVLAVLGAVVAVVMCRRKSSGGKGGSCSQAASSN SAQGSDESLIACKA

Database cross reference

RefSeq Protein accession:NP_002108
RefSeq Protein gi:52630342

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0042612;C:MHC class I protein complex;IEA:UniProtKB-KW.

GO-P

GO:0002474;P:antigen processing and presentation of peptide antigen via MHC class I;IEA:UniProtKB-KW. GO:0006955;P:immune response;IEA:InterPro. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW.

TCR

IL1

RANKL