Protein basic information
| LiverAtlas Protein ID |
HuLPr00046 |
|
Uniprot ID |
|
|
Uniprot Acc |
P30153;Q13773;Q6ICQ3;Q96DH3; |
|
Protein name |
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform |
|
Comment |
FUNCTION:The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.||SUBUNIT:Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with TP53 and SGOL1.||INTERACTION:P03081:- (xeno); NbExp=1; IntAct=EBI-302388, EBI-1266256; Q9NSA3:CTNNBIP1; |
|
Subcellular localization |
Cytoplasm(By similarity).Chromosome, centromere. |
|
Gene name |
|
|
Related liver disease name |
|
|
Protein sequence
|
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIAL ALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTL VGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHE HSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPR VSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVL ELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLL PQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAV GPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENL SADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGL SPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCV NEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLL AGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKL VEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVL SEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKI GPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA |
|
Database cross reference |
RefSeq Protein accession:NP_055040
|
Liver relevance
|
HCC significant Proteins |
Yes/No |
Yes |
|
Quality score |
|
|
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Fetal Liver;French Liver;Human Liver Organelles;Chinese Liver; |
Ontology annotation
| GO-C |
GO:0000775;C:chromosome, centromeric region;IDA:UniProtKB. GO:0005829;C:cytosol;TAS:UniProtKB. GO:0016020;C:membrane;NAS:UniProtKB. GO:0015630;C:microtubule cytoskeleton;NAS:UniProtKB. GO:0005739;C:mitochondrion;NAS:UniProtKB. GO:0005634;C:nucleus;NAS |
|
GO-F |
GO:0003823;F:antigen binding;IPI:UniProtKB. GO:0046982;F:protein heterodimerization activity;IPI:UniProtKB. GO:0008601;F:protein phosphatase type 2A regulator activity;TAS:UniProtKB. |
|
GO-P |
GO:0006672;P:ceramide metabolic process;NAS:UniProtKB. GO:0007059;P:chromosome segregation;IDA:UniProtKB. GO:0000086;P:G2/M transition of mitotic cell cycle;TAS:Reactome. GO:0000188;P:inactivation of MAPK activity;NAS:UniProtKB. GO:0006917;P:induction |