Protein basic information
| LiverAtlas Protein ID |
HuLPr00682 |
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Uniprot ID |
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Uniprot Acc |
P01023;Q13677;Q59F47;Q5QTS0;Q68DN2;Q6PIY3;Q6PN97; |
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Protein name |
Alpha-2-macroglobulin |
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Comment |
FUNCTION:Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.||SUBUNIT:Homotetramer; disulfide-linked.||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Secreted in plasma.||DEVELOPMENTAL STAGE:Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.||SIMILARITY:Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.||SEQUENCE CAUTION:Sequence=AAT02 |
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Subcellular localization |
Secreted. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLH TETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLEA ENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRT TVMVKNEDSLVFVQTDKSIYKPGQTVKFRVVSMDENFHP LNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSS EPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTV PKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSD ASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKTKVFQLKR KEYEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKLSF VKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEA NYYSNATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSP CYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELP CGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRT GTHGLLVKQEDMKGHFSISIPVKSDIAPVARLLIYAVLP TGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLR VTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEK DLTGFPGPLNDQDNEDCINRHNVYINGITYTPVSSTNEK DMYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGPEGL RVGFYESDVMGRGHARLVHVEEPHTETVRKYFPETWIWD LVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGIS STASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPK CIRVSVQLEASPAFLAVPVEKEQAPHCICANGRQTVSWA VTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDT VIKPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPP NVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQN MVLFAPNIYVLDYLNETQQLTPEI |
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Database cross reference |
RefSeq Protein accession:NP_000005
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Fetal Liver;Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;TAS:Reactome. GO:0005615;C:extracellular space;IEA:InterPro. GO:0031093;C:platelet alpha granule lumen;TAS:Reactome. |
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GO-F |
GO:0019899;F:enzyme binding;IPI:UniProtKB. GO:0005096;F:GTPase activator activity;TAS:Reactome. GO:0019966;F:interleukin-1 binding;IDA:UniProtKB. GO:0019959;F:interleukin-8 binding;IPI:UniProtKB. GO:0004867;F:serine-type endopeptidase inhibitor activit |
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GO-P |
GO:0007597;P:blood coagulation, intrinsic pathway;TAS:Rea |