HuLPr03573

Uniprot ID

AACS_HUMAN

Uniprot Acc

Q86V21;Q49AB9;Q49AC3;Q658Q8;Q8IWD2;Q8NEW5;Q9BSJ9;Q9H829;Q9HA19;

Protein name

Acetoacetyl-CoA synthetase

Comment

FUNCTION:Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).||CATALYTIC ACTIVITY:ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.||SUBCELLULAR LOCATION:Cytoplasm, cytosol (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q86V21-1; Sequence=Displayed; Name=2; IsoId=Q86V21-2; Sequence=VSP 030702; Note=No experimental confirmation available; Name=3; IsoId=Q86V21-3; Sequence=VSP 030701; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Highly expressed in kidney, heart and brain, but low in liver.||SIMILARITY:Belongs to the ATP-dependent AMP-binding enzyme family.||SEQUENCE CAUTION:Sequence=AAH41000.1; Type=Frameshift; Positions=201; Sequence=BAB14793.1; Type=Frameshift; Positions=519;

Subcellular localization

Cytoplasm, cytosol(By similarity).

Gene name

acetoacetyl-CoA synthetase

Protein sequence

MSKEERPGREEILECQVMWEPDSKKNTQMDRFRAAVGAAC GLALESYDDLYHWSVESYSDFWAEFWKFSGIVFSRVYDE VVDTSKGIADVPEWFKGSRLNYAENLLRHKENDRVALYI AREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVV GYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRF SQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKK VVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQL EFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLK EHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLATGAAMV LYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEK AMKPVETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSSI LLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVE AWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYR KAYFSKFPGIWAHGDYCRINPKTGGIVMLGRSDGTLNPN GVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILF LKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKG IPYTLNGKKVEVAVKQIIAGKAVEQGGAFSNPETLDLYRDIPELQGF

Database cross reference

RefSeq Protein accession:NP_076417
RefSeq Protein gi:31982927

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005829;C:cytosol;IEA:UniProtKB-SubCell.

GO-F

GO:0030729;F:acetoacetate-CoA ligase activity;IEA:EC. GO:0005524;F:ATP binding;IEA:UniProtKB-KW.

GO-P

GO:0006631;P:fatty acid metabolic process;IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr03573

PHOSPHORYLATION

212

Y

PhosphoSitePlus

13830000

LTP

N

2-Hydroxyglutric_Aciduria_(D_And_L_Form)