Protein basic information
| LiverAtlas Protein ID |
HuLPr12917 |
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Uniprot ID |
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Uniprot Acc |
Q9BUT1;A8K295;B4DUF6;Q503A0;Q6IA46;Q6UWD3;Q9H8S8;Q9NRX8; |
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Protein name |
3-hydroxybutyrate dehydrogenase type 2 |
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Comment |
FUNCTION:Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity).||CATALYTIC ACTIVITY:(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=60 uM for NAD; KM=10 mM for R-hydroxybutyrate; Vmax=82 nmol/min/mg enzyme (at 30 degrees Celsius); pH dependence: Optimum pH is 7.5-9.0;||PATHWAY:Siderophore biosynthesis.||SUBUNIT:Homotetramer.||SUBCELLULAR LOCATION:Cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BUT1-1; Sequence=Displayed; Name=2; IsoId=Q9BUT1-2; Sequence=VSP 015859; Name=3; IsoId=Q9BUT1-3; Sequence=VSP 039781;||SIMILARITY:Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
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Subcellular localization |
Cytoplasm. |
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Gene name |
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Protein sequence
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MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINE SKLQELEKYPGIQTRVLDVTKKKQIDQFANEVERLDVLF NVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLP KMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGL TKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARGNPE EARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGN PVIIDGGWSL |
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Database cross reference |
RefSeq Protein accession:NP_064524
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:HGNC. |
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GO-F |
GO:0003858;F:3-hydroxybutyrate dehydrogenase activity;IDA:HGNC. GO:0051287;F:NAD binding;IDA:HGNC. GO:0016628;F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;ISS:UniProtKB. |
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GO-P |
GO:0006635;P:fatty acid beta-oxidation;IDA:HGNC. GO:0042168;P:heme metabolic process;ISS:UniProtKB. GO:0055072;P:iron ion homeostasis;ISS:UniProtKB. GO:0019290;P:siderophore biosynthetic process;ISS:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr12917 |
ACETYLATION |
151 |
K |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr12917 |
ACETYLATION |
48 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr12917 |
PHOSPHORYLATION |
132 |
S |
PhosphoSitePlus |
HTP |
N |
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Pathway
| Pathway name |
