HuLPr15935

Uniprot ID

CO1A2_HUMAN

Uniprot Acc

P08123;P02464;Q13897;Q13997;Q13998;Q14038;Q14057;Q15177;Q15947;Q16480;Q16511;Q7Z5S6;Q9UEB6;Q9UEF9;Q9UM83;Q9UMI1;Q9UML5;Q9UMM6;Q9UPH0;

Protein name

Collagen alpha-2(I) chain

Comment

FUNCTION:Type I collagen is a member of group I collagen (fibrillar forming collagen).||SUBUNIT:Trimers of one alpha 2(I) and two alpha 1(I) chains.||INTERACTION:Q5YB85:- (xeno); NbExp=1; IntAct=EBI-983038, EBI-982988;||SUBCELLULAR LOCATION:Secreted, extracellular space, extracellular matrix (By similarity).||TISSUE SPECIFICITY:Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.||PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.||DISEASE:Defects in COL1A2 are the cause of Ehlers-Danlos syndrome type 7B (EDS7B) [MIM:130060]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7B is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations.||DISEASE:Defects in COL1A2 are a cause of osteogenesis imperfecta

Subcellular localization

Secreted, extracellular space, extracellular matrix(By similarity).

Gene name

collagen, type I, alpha 2

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGP RGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAA QYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAG EPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERG VVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPG VKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARG SDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAG PAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAG LPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAG SKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAG PPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAG VRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVG LPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNG DKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQG PPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAG PRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPG VVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRG EIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAG PAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERG AKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGG PPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRG PRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPG TPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLG IAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPG RDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHG NRGETGPSGPVGPAGAVGPRGPSG

Database cross reference

RefSeq Protein accession:NP_000080
RefSeq Protein gi:48762934

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005584;C:collagen type I;IDA:UniProtKB. GO:0005615;C:extracellular space;IDA:UniProtKB. GO:0005886;C:plasma membrane;EXP:Reactome.

GO-F

GO:0005201;F:extracellular matrix structural constituent;NAS:UniProtKB. GO:0042802;F:identical protein binding;IDA:UniProtKB. GO:0048407;F:platelet-derived growth factor binding;IDA:MGI. GO:0030674;F:protein binding, bridging;IMP:UniProtKB.

GO-P