HuLPr18441

Uniprot ID

DISP1_HUMAN

Uniprot Acc

Q96F81;Q8N7C2;Q96I92;Q9H698;Q9H8H9;Q9UFA2;

Protein name

Protein dispatched homolog 1

Comment

FUNCTION:Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity).||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Potential).||SIMILARITY:Belongs to the dispatched family.||SIMILARITY:Contains 1 SSD (sterol-sensing) domain.||SEQUENCE CAUTION:Sequence=AAH07734.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB14637.1; Type=Frameshift; Positions=1391, 1393, 1413; Sequence=BAB15365.1; Type=Erroneous initiation;

Subcellular localization

Membrane;Multi-pass membrane protein(Potential).

Gene name

dispatched homolog 1 (Drosophila)

Protein sequence

MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQL TPKEATRTKVSPNGCLQLNGTVKSSFLPLDNQRMPQMLP QCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQ PHSEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHF QHQPVQQHIANIRPSRPFKLPKSYAALIADWPVVVLGMC TMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLV TWNNMVKNTGYKATLANYPFKYADEQAKSHRDDRWSDDH YEREKREVDWNFHKDSFFCDVPSDRYSRVVFTSSGGETL WNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSW TLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQN GTLGPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHY LVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYL DNFENWNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPA IAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYR VVFHFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKF DKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVS NITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLL NIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASR IFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKM KLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHGE ELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIAS PASQAWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQW MENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELE RSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAY EKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDL QDSLSDGTLIAMGLSVAVAFSVML

Database cross reference

RefSeq Protein accession:NP_116279
RefSeq Protein gi:25952134

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0016323;C:basolateral plasma membrane;ISS:UniProtKB. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0008158;F:hedgehog receptor activity;IEA:InterPro. GO:0015197;F:peptide transporter activity;ISS:UniProtKB.

GO-P

GO:0060539;P:diaphragm development;IMP:UniProtKB. GO:0070207;P:protein homotrimerization;ISS:UniProtKB. GO:0050708;P:regulation of protein secretion;ISS:UniProtKB. GO:0007224;P:smoothened signaling pathway;ISS:UniProtKB.

Hedgehog