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Protein basic information

LiverAtlas Protein ID

HuLPr24677

Uniprot ID

HHAT_HUMAN

Uniprot Acc

Q5VTY9;D3DT91;Q17RZ7;Q4G0K3;Q5CZ95;Q5TGI2;Q9NVH9;Q9Y3N8;

Protein name

Protein-cysteine N-palmitoyltransferase HHAT

Comment

FUNCTION:Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (By similarity). May bind GTP.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5VTY9-1; Sequence=Displayed; Name=2; IsoId=Q5VTY9-2; Sequence=VSP 016686, VSP 016689; Name=3; IsoId=Q5VTY9-3; Sequence=VSP 016689; Note=No experimental confirmation available; Name=4; IsoId=Q5VTY9-4; Sequence=VSP 016685, VSP 016687, VSP 016688;||TISSUE SPECIFICITY:Ubiquitously expressed in normal tissues and cancer cell lines.||SIMILARITY:Belongs to the membrane-bound acyltransferase family. HHAT subfamily.

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein(By similarity).

Gene name

hedgehog acyltransferase

Protein sequence

MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEF ELETDTLFGGLKKDATDFEWSFWMEWGKQWLVWLLLGHM VVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVL LHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKR RWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAAS TSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHD SLKASLCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSI PLLETVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRL DGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYI PVGGSQHGLLGTLFSTAMTFAFVSYWHGGYDYLWCWAAL NWLGVTVENGVRRLVETPCIQDSLARYFSPQARRRFHAA LASCSTSMLILSNLVFLGGNEVGKTYWNRIFIQGWPWVT LSVLGFLYCYSHVGIAWAQTYATD

Database cross reference

RefSeq Protein accession:NP_001116306
RefSeq Protein gi:170784863

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005525;F:GTP binding;IEA:UniProtKB-KW.

GO-P

GO:0007275;P:multicellular organismal development;IEA:UniProtKB-KW.

Pathway

Pathway name

Signaling_events_mediated_by_the_Hedgehog_family

Pathway name

Hedgehog