Protein basic information
| LiverAtlas Protein ID |
HuLPr24680 |
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Uniprot ID |
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Uniprot Acc |
Q96QV1;Q6PK09;Q8NCI7;Q9BXK3;Q9H1J4;Q9H7E7; |
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Protein name |
Hedgehog-interacting protein |
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Comment |
FUNCTION:Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.||SUBUNIT:Interacts with all three hedgehog family members, SHH, IHH and DHH.||SUBCELLULAR LOCATION:Cell membrane; Peripheral membrane protein (By similarity). Secreted (By similarity). Note=The last 22 C- terminal amino acids may participate in cell membrane attachment.||SUBCELLULAR LOCATION:Isoform 2:Cytoplasm (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96QV1-1; Sequence=Displayed; Name=2; IsoId=Q96QV1-2; Sequence=VSP 013192, VSP 013193; Note=Potentially soluble form;||TISSUE SPECIFICITY:Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.||DOMAIN:A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding.||POLYMORPHISM:Genetic variations in HHIP define the stature quantitative trait lo |
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Subcellular localization |
Cell membrane;Peripheral membrane protein(By similarity).Secreted(By similarity). |
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Gene name |
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Protein sequence
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MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCL NGNPPKRLKRRDRRMMSQLELLSGGEMLCGGFYPRLSCC LRSDSPGLGRLENKIFSVTNNTECGKLLEEIKCALCSPH SQSLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRGHIP GFLQTTADEFCFYYARKDGGLCFPDFPRKQVRGPASNYL DQMEEYDKVEEISRKHKHNCFCIQEVVSGLRQPVGALHS GDGSQRLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQS GIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIG PHDHILRVVEYTVSRKNPHQVDLRTARVFLEVAELHRKH LGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGS VLRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLH DPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQII KGKDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYGS YVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTSGSCRGYF SGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPK RPLMPEECRATVQPAQTLTSECSRLCRNGYCTPTGKCCC SPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGP QCEQVDRNIRRVTRAGILDQIIDMTSYLLDLTSYIV |
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Database cross reference |
RefSeq Protein accession:NP_071920
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0003824;F:catalytic activity;IEA:InterPro. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0008270;F:zinc ion binding;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr24680 |
PHOSPHORYLATION |
293 |
Y |
PhosphoSitePlus |
LTP |
N |
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|
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HuLPr24680 |
PHOSPHORYLATION |
265 |
Y |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name | |
| Pathway name |
