Protein basic information
| LiverAtlas Protein ID |
HuLPr26983 |
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Uniprot ID |
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Uniprot Acc |
Q14676;A2AB04;A2BF04;A2RRA8;A7YY86;B0S8A2;Q0EFC2;Q2L6H7;Q2TAZ4;Q5JP55;Q5JP56;Q5ST83;Q68CQ3;Q86Z06;Q96QC2; |
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Protein name |
Mediator of DNA damage checkpoint protein 1 |
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Comment |
FUNCTION:Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1/CHK1 and CHEK2/CHK2/CDS1 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.||SUBUNIT:Interacts with several proteins involved in the DNA damage response, although not all these interactions may be direct. Interacts with H2AFX, which requires phosphorylation of H2AFX on 'Ser-139'. Interacts with the MRN complex, composed of MRE11A/MRE11, RAD50, and NBN. Interacts with CHEK2/CHK2/CDS1, which requires ATM-mediated phosphorylation of 'Thr- |
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Subcellular localization |
Nucleus. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MEDTQAIDWDVEEEEETEQSSESLRCNVEPVGRLHIFSGA HGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIE ILAWDKAPILRDCGSLNGTQILRPPKVLSPGVSHRLRDQ ELILFADLLCQYHRLDVSLPFVSRGPLTVEETPRVQGET QPQRLLLAEDSEEEVDFLSERRMVKKSRTTSSSVIVPES DEEGHSPVLGGLGPPFAFNLNSDTDVEEGQQPATEEASS AARRGATVEAKQSEAEVVTEIQLEKDQPLVKERDNDTKV KRGAGNGVVPAGVILERSQPPGEDSDTDVDDDSRPPGRP AEVHLERAQPFGFIDSDTDAEEERIPATPVVIPMKKRKI FHGVGTRGPGAPGLAHLQESQAGSDTDVEEGKAPQAVPL EKSQASMVINSDTDDEEEVSAALTLAHLKESQPAIWNRD AEEDMPQRVVLLQRSQTTTERDSDTDVEEEELPVENREA VLKDHTKIRALVRAHSEKDQPPFGDSDDSVEADKSSPGI HLERSQASTTVDINTQVEKEVPPGSAIIHIKKHQVSVEG TNQTDVKAVGGPAKLLVVSLEEAWPLHGDCETDAEEGTS LTASVVADVRKSQLPAEGDAGAEWAAAVLKQERAHEVGA QGGPPVAQVEQDLPISRENLTDLVVDTDTLGESTQPQRE GAQVPTGREREQHVGGTKDSEDNYGDSEDLDLQATQCFL ENQGLEAVQSMEDEPTQAFMLTPPQELGPSHCSFQTTGT LDEPWEVLATQPFCLRESEDSETQPFDTHLEAYGPCLSP PRAIPGDQHPESPVHTEPMGIQGRGRQTVDKVMGIPKET AERVGPERGPLERETEKLLPERQTDVTGEEELTKGKQDR EQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSE EIQEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKV PKVILERDTQRGEPEGGSQDQKGQASSPTPEPGVGAGDL PGPTSAPVPSGSQSGGRGSPVSPR |
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Database cross reference |
RefSeq Protein accession:NP_055456
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005925;C:focal adhesion;IDA:HPA. GO:0005654;C:nucleoplasm;EXP:Reactome. |
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GO-F |
GO:0070975;F:FHA domain binding;IPI:UniProtKB. GO:0008022;F:protein C-terminus binding;IPI:UniProtKB. |
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GO-P |
GO:0007049;P:cell cycle;IEA:UniProtKB-KW. GO:0000724;P:double-strand break repair via homologous recombination;TAS:Reactome. GO:0031573;P:intra-S DNA damage checkpoint;TAS:UniProtKB. |