HuLPr26992

Uniprot ID

MDM2_HUMAN

Uniprot Acc

Q00987;A6NL51;A8K2S6;Q13226;Q13297;Q13298;Q13299;Q13300;Q13301;Q53XW0;Q71TW9;Q8WYJ1;Q8WYJ2;Q9UGI3;Q9UMT8;

Protein name

E3 ubiquitin-protein ligase Mdm2

Comment

FUNCTION:E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.||SUBUNIT:Binds p53/TP53, TP73/p73, ARF/P14, PML, RBL5 and RP11, and specifically to RNA. Can interact with RB1, E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with p53/TP53 and WWOX. Interacts with CDKN2AIP, MTBP, RFWD3, TBRG1, USP7, PY

Subcellular localization

Nucleus, nucleoplasm.Cytoplasm.Nucleus, nucleolus.

Gene name

Mdm2 p53 binding protein homolog (mouse)

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKS VGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSN DLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDS GTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPS TSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDES LALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDW LDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDE VYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNP PLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQ AEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQES EDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSL PLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLK KRNKPCPVCRQPIQMIVLTYFP

Database cross reference

RefSeq Protein accession:NP_002383
RefSeq Protein gi:89993689

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;

GO:0005829;C:cytosol;EXP:Reactome. GO:0030666;C:endocytic vesicle membrane;EXP:Reactome. GO:0005626;C:insoluble fraction;IDA:UniProtKB. GO:0005730;C:nucleolus;IDA:UniProtKB. GO:0005654;C:nucleoplasm;IDA:UniProtKB. GO:0005886;C:plasma membrane;EXP:Reac

GO-F

GO:0017163;F:basal transcription repressor activity;IDA:UniProtKB. GO:0019899;F:enzyme binding;IPI:UniProtKB. GO:0042802;F:identical protein binding;IPI:IntAct. GO:0002039;F:p53 binding;IPI:UniProtKB. GO:0004842;F:ubiquitin-protein ligase activity;IDA:

GO-P

GO:0071456;P:cellular response to hypoxia;IEP:UniProtKB. GO:0006977;P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;TAS:Reactome. GO:0045184;P:establishment of protein localization;IDA:BHF-UCL. GO:0044419;