Protein basic information
| LiverAtlas Protein ID |
HuLPr28147 |
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Uniprot ID |
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Uniprot Acc |
P35228;A1L3U5;B7ZLY2;O60757;O94994;Q16263;Q16692;Q4TTS5;Q9UD42; |
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Protein name |
Nitric oxide synthase, inducible |
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Comment |
FUNCTION:Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.||CATALYTIC ACTIVITY:L-arginine + n NADPH + n H(+) + m O(2) = citrulline + nitric oxide + n NADP(+).||COFACTOR:Heme group (By similarity).||COFACTOR:Binds 1 FAD (By similarity).||COFACTOR:Binds 1 FMN (By similarity).||COFACTOR:Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme (By similarity).||ENZYME REGULATION:Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity (By similarity).||SUBUNIT:Homodimer. Binds SLC9A3R1.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35228-1; Sequence=Display |
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Gene name |
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Protein sequence
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MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVT QDDLQYHNLSKQQNESPQPLVETGKKSPESLVKLDATPL SSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGS IMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEA KIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRN APRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYST NNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPD GSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANG RDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAV ANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNI LEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQN VTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMS GSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRP KRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATET GKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLL LVVTSTFGNGDCPGNGEKLKKSLFMLKELNNKFRYAVFG LGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSG QEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVT WDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQN LQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQP ALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLP PCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRL EALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLS QLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQG PLHHGVCSTWLNSLKPQDPVPCFVRNASGFHLPEDPSHP CILIGPGTGIAPFRSFWQQRLHDS |
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Database cross reference |
RefSeq Protein accession:NP_000616
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
French Liver; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;IMP:BHF-UCL. GO:0005634;C:nucleus;ISS:BHF-UCL. |
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GO-F |
GO:0034618;F:arginine binding;ISS:BHF-UCL. GO:0005516;F:calmodulin binding;IEA:UniProtKB-KW. GO:0050660;F:flavin adenine dinucleotide binding;ISS:BHF-UCL. GO:0010181;F:FMN binding;ISS:BHF-UCL. GO:0020037;F:heme binding;ISS:BHF-UCL. GO:0050661;F:NADP b |
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GO-P |
GO:0006527;P:arginine catabolic process;IDA:BHF-UCL. GO:0050829;P:defense response to Gram-negative bacterium;NAS:BHF-UCL. GO:0002227;P:innate immune response in mucosa;NAS:BHF-UCL. GO:0006809;P:nitric oxide biosynthetic process;IDA:BHF-UCL. GO:0055114 |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr28147 |
PHOSPHORYLATION |
868 |
Y |
PhosphoSitePlus |
HTP |
N |
 
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HuLPr28147 |
PHOSPHORYLATION |
1055 |
Y |
PhosphoSitePlus |
HTP |
N |
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|
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HuLPr28147 |
PHOSPHORYLATION |
151 |
Y |
PhosphoSitePlus |
LTP |
N |
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HuLPr28147 |
PHOSPHORYLATION |
745 |
S |
PhosphoSitePlus |
LTP HTP |
N |
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Pathway
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| Pathway name | |
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| Pathway name | |
| Pathway name | |
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