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Protein basic information

LiverAtlas Protein ID

HuLPr34462

Uniprot ID

Q59FK4_HUMAN

Uniprot Acc

Q59FK4;

Protein name

V-abl Abelson murine leukemia viral oncogene homolog 1 isoform b variant

Comment

CATALYTIC ACTIVITY:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.||SIMILARITY:Contains 1 SH2 domain.||SIMILARITY:Contains 1 SH3 domain.||SIMILARITY:Contains 1 protein kinase domain.

Gene name

c-abl oncogene 1, non-receptor tyrosine kinase

Protein sequence

PFWKILNPLLERGTYYYFMGQQPGKVLGDQRRPSLPALHF IKGAGKKESSRHGGPHCNVFVEHEALQRPVASDFEPQGL SEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLS ITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPG QRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAEL VHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEM ERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKED TMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIIT EFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYL EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTY TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEI ATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYEL MRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKEL GKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPE MPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDE RLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQ PERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGA GVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEG GGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTG RQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPP PRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQV TVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGA PGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVD AVNSDAAKPSQPGEGLKKPVLPAT

Database cross reference

RefSeq Protein accession:NP_005148
RefSeq Protein gi:62362414

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005634;C:nucleus;IDA:HPA.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004715;F:non-membrane spanning protein tyrosine kinase activity;IEA:InterPro.