Protein basic information
| LiverAtlas Protein ID |
HuLPr46011 |
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Uniprot ID |
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Uniprot Acc |
P36952;B2R6Y4;Q6N0B4;Q8WW89; |
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Protein name |
Serpin B5 |
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Comment |
FUNCTION:Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.||SUBUNIT:Interacts with IRF6.||SUBCELLULAR LOCATION:Secreted, extracellular space.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P36952-1; Sequence=Displayed; Name=2; IsoId=P36952-2; Sequence=VSP 037145, VSP 037146;||TISSUE SPECIFICITY:Normal mammary epithelial cells.||SIMILARITY:Belongs to the serpin family. Ov-serpin subfamily.||WEB RESOURCE:Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SerpinB5ID42267.html"; |
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Subcellular localization |
Secreted, extracellular space. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLS LAQVGAKGDTANEIGQVLHFENVKDVPFGFQTVTSDVNK LSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELET VDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQT KILVVNAAYFVGKWMKKFSESETKECPFRVNKTDTKPVQ MMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKD VEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIP KFKVEKMIDPKACLENLGLKHIFSEDTSDFSGMSETKGV ALSNVIHKVCLEITEDGGDSIEVPGARILQHKDELNADH PFIYIIRHNKTRNIIFFGKFCSP |
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Database cross reference |
RefSeq Protein accession:NP_002630
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:UniProtKB. GO:0005615;C:extracellular space;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0005515;F:protein binding;IPI:UniProtKB. GO:0004867;F:serine-type endopeptidase inhibitor activity;ISS:RefGenome. |
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GO-P |
GO:0006928;P:cellular component movement;TAS:ProtInc. GO:0030162;P:regulation of proteolysis;ISS:RefGenome. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr46011 |
PHOSPHORYLATION |
9 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
PHOSPHORYLATION |
135 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
PHOSPHORYLATION |
356 |
Y |
PhosphoSitePlus |
HTP |
N |
|
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HuLPr46011 |
ACETYLATION |
277 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
ACETYLATION |
280 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
PHOSPHORYLATION |
157 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
PHOSPHORYLATION |
118 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
PHOSPHORYLATION |
97 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
PHOSPHORYLATION |
240 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
PHOSPHORYLATION |
298 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
PHOSPHORYLATION |
316 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
PHOSPHORYLATION |
310 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr46011 |
PHOSPHORYLATION |
50 |
T |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name | |
| Pathway name | |
| Pathway name |
