| Conclusion | HLA-DRB1 * 0301, -DQA1 * 0501 and -DQB1 * 0301 were closely associated with the susceptibility to HuLDi00023, while HLA-DRB1 * 1101/1104 and -DQA1 * 0301 closely associated with the resistance to HuLDi00023. These findings suggested that host HLA class II gene was an important factor determining the outcome of HBV infection.;Non-response to interferon-alpha therapy is positively correlated with HLA-DRB1*04 and HLA-DQA1*0303, and negatively correlated with HLA-DQA1*0505 and -DQB1*0301 in patient with chronic viral HuLDi00022. HLA II genes of the identification alleles provide a method for evaluating outcome of interferon-alpha treatment.;HLA-DRB1*0301, HLA-DQA1*0501 and HLA-DQB1*0301 are closely related with susceptibility to HuLDi00023, and HLA-DRB1*1101/1104 and HLA-DQA1*0301 are closely related with resistance to HuLDi00023. These findings suggest that host HLA class II gene is an important factor determining the outcome of HBV infection.;HLA phenotype, which varies with different regions, is one of the factors in persistence of HuLDi00022 infection.;Our results indicate that alleles of A33, DR7, and haplotypes containing DR7 are associated with HBV chronicity among Koreans.Conclusion1 |
