| Conclusion | Heterozygosity for CCR5delta32 was shown to be significantly associated with spontaneous HuLDi00024 viral clearance and with significantly lower hepatic inflammatory scores in subgroups within this cohort. Both controls and the HCV population had similar heterozygosity frequencies.;In this cohort, the frequency of CCR5Delta32 homozygosity in patients with HuLDi00024 was similar to controls. The high prevalence of CCR5Delta32 homozygosity in the HuLDi00024 virus patients of the earlier study likely reflects resistance to human immunodeficiency virus infection in hemophiliacs rather than a susceptibility to HuLDi00024. Expression of CCR5 and RANTES may be important in the modulation of hepatic inflammation and response to interferon therapy in HuLDi00025.Conclusion1 |
