Gene basic information
| LiverAtlas Gene ID |
HuLG000002 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
A2M |
|
Synonyms |
CPAMD5|DKFZp779B086|S863-7 |
|
Gene name |
alpha-2-macroglobulin |
|
Gene Type |
protein-coding |
|
Chromosome |
12 |
|
Genomics Location |
12p13.31 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
Liver fibrosis and liver cirrhosis Liver fibrosis and liver cirrhosis caused by hepatitis C infection |
|
Database cross reference |
HGNC:7
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0001869 |
negative regulation of complement activation, lectin pathway |
|
GO:0002576 |
platelet degranulation |
|
GO:0004867 |
serine-type endopeptidase inhibitor activity |
|
GO:0005096 |
GTPase activator activity |
|
GO:0005515 |
protein binding |
|
GO:0005576 |
extracellular region |
|
GO:0005615 |
extracellular space |
|
GO:0005829 |
cytosol |
|
GO:0006953 |
acute-phase response |
|
GO:0007264 |
small GTPase mediated signal transduction |
|
GO:0007584 |
response to nutrient |
|
GO:0007596 |
blood coagulation |
|
GO:0007597 |
blood coagulation, intrinsic pathway |
|
GO:0010037 |
response to carbon dioxide |
|
GO:0019838 |
growth factor binding |
|
GO:0019899 |
enzyme binding |
|
GO:0019959 |
interleukin-8 binding |
|
GO:0019966 |
interleukin-1 binding |
|
GO:0030168 |
platelet activation |
|
GO:0031093 |
platelet alpha granule lumen |
|
GO:0043120 |
tumor necrosis factor binding |
|
GO:0043547 |
positive regulation of GTPase activity |
|
GO:0051056 |
regulation of small GTPase mediated signal transduction |
|
GO:0051384 |
response to glucocorticoid stimulus |
