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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG000005

Entrez Gene ID

12

Official Gene Symbol

SERPINA3

Synonyms

AACT|ACT|GIG25|MGC88254

Gene name

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

Gene Type

protein-coding

Chromosome

14

Genomics Location

14q32.1

Known cancer genes

Yes

Protein products

Alpha-1-antichymotrypsin

Actin-like protein

Actin-like protein

Actin-like protein

Actin-like protein

Actin-like protein

Actin-like protein

Actin-like protein

Actin-like protein

Related liver disease name

Liver fibrosis and liver cirrhosis

Chronic hepatitis

Hepatocellular carcinoma

Database cross reference

HGNC:16
MIM:107280
Ensembl:ENSG00000196136
HPRD:00120
RefSeq Genomic nucleotide accession:AC_000057
RefSeq Genomic nucleotide gi:89161192

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0003677

DNA binding

GO:0004867

serine-type endopeptidase inhibitor activity

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005622

intracellular

GO:0005634

nucleus

GO:0006953

acute-phase response

GO:0006954

inflammatory response

GO:0010951

negative regulation of endopeptidase activity

GO:0019216

regulation of lipid metabolic process

GO:0030162

regulation of proteolysis

GO:0030277

maintenance of gastrointestinal epithelium

GO:0030414

peptidase inhibitor activity