Gene basic information
| LiverAtlas Gene ID |
HuLG000018 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
ABL1 |
|
Synonyms |
ABL|JTK7|bcr/abl|cNABL|p150|vNabl |
|
Gene name |
c-abl oncogene 1, non-receptor tyrosine kinase |
|
Gene Type |
protein-coding |
|
Chromosome |
9 |
|
Genomics Location |
9q34.1 |
|
Known cancer genes |
Yes |
|
Protein products |
V-abl Abelson murine leukemia viral oncogene homolog 1 isoform b variant |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:76
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000115 |
regulation of transcription involved in S phase of mitotic cell cycle |
|
GO:0000166 |
nucleotide binding |
|
GO:0000287 |
magnesium ion binding |
|
GO:0003677 |
DNA binding |
|
GO:0004713 |
protein tyrosine kinase activity |
|
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005634 |
nucleus |
|
GO:0005730 |
nucleolus |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0005856 |
cytoskeleton |
|
GO:0006298 |
mismatch repair |
|
GO:0006355 |
regulation of transcription, DNA-dependent |
|
GO:0006464 |
protein modification process |
|
GO:0006975 |
DNA damage induced protein phosphorylation |
|
GO:0007155 |
cell adhesion |
|
GO:0007411 |
axon guidance |
|
GO:0007596 |
blood coagulation |
|
GO:0008022 |
protein C-terminus binding |
|
GO:0008630 |
DNA damage response, signal transduction resulting in induction of apoptosis |
|
GO:0016020 |
membrane |
|
GO:0017124 |
SH3 domain binding |
|
GO:0018108 |
peptidyl-tyrosine phosphorylation |
|
GO:0030036 |
actin cytoskeleton organization |
|
GO:0030145 |
manganese ion binding |
|
GO:0031965 |
nuclear membrane |
|
GO:0042692 |
muscle cell differentiation |
|
GO:0048471 |
perinuclear region of cytoplasm |
|
GO:0051019 |
mitogen-activated protein kinase binding |
|
GO:0051149 |
positive regulation of muscle cell differentiation |
|
GO:0051353 |
positive regulation of oxidoreductase activity |
|
GO:0070064 |
proline-rich region binding |
|
GO:0071901 |
negative regulation of protein serine/threonine kinase activity |
