Gene basic information
| LiverAtlas Gene ID |
HuLG000067 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
ADAM8 |
|
Synonyms |
CD156|MGC134985|MS2 |
|
Gene name |
ADAM metallopeptidase domain 8 |
|
Gene Type |
protein-coding |
|
Chromosome |
10 |
|
Genomics Location |
10q26.3 |
|
Known cancer genes |
Yes |
|
Protein products |
Disintegrin and metalloproteinase domain-containing protein 8 cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8) |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:215
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000902 |
cell morphogenesis |
|
GO:0001525 |
angiogenesis |
|
GO:0002102 |
podosome |
|
GO:0002523 |
leukocyte migration involved in inflammatory response |
|
GO:0002675 |
positive regulation of acute inflammatory response |
|
GO:0002687 |
positive regulation of leukocyte migration |
|
GO:0002693 |
positive regulation of cellular extravasation |
|
GO:0004222 |
metalloendopeptidase activity |
|
GO:0005509 |
calcium ion binding |
|
GO:0005515 |
protein binding |
|
GO:0005737 |
cytoplasm |
|
GO:0005886 |
plasma membrane |
|
GO:0005887 |
integral to plasma membrane |
|
GO:0006508 |
proteolysis |
|
GO:0006954 |
inflammatory response |
|
GO:0008233 |
peptidase activity |
|
GO:0008237 |
metallopeptidase activity |
|
GO:0008270 |
zinc ion binding |
|
GO:0009986 |
cell surface |
|
GO:0010954 |
positive regulation of protein maturation by peptide bond cleavage |
|
GO:0022407 |
regulation of cell-cell adhesion |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0032010 |
phagolysosome |
|
GO:0032127 |
dense core granule membrane |
|
GO:0033089 |
positive regulation of T cell differentiation in thymus |
|
GO:0035419 |
activation of MAPK activity involved in innate immune response |
|
GO:0042581 |
specific granule |
|
GO:0043524 |
negative regulation of neuron apoptosis |
|
GO:0043621 |
protein self-association |
|
GO:0045780 |
positive regulation of bone resorption |
|
GO:0045785 |
positive regulation of cell adhesion |
|
GO:0048247 |
lymphocyte chemotaxis |
|
GO:0050714 |
positive regulation of protein secretion |
|
GO:0050839 |
cell adhesion molecule binding |
|
GO:0051044 |
positive regulation of membrane protein ectodomain proteolysis |
|
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
|
GO:0051897 |
positive regulation of protein kinase B signaling cascade |
|
GO:0070245 |
positive regulation of thymocyte apoptosis |
|
GO:0070820 |
tertiary granule |
|
GO:0071065 |
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex |
|
GO:0071133 |
alpha9-beta1 integrin-ADAM8 complex |
|
GO:0071456 |
cellular response to hypoxia |
|
GO:2000309 |
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production |
