Gene basic information
| LiverAtlas Gene ID |
HuLG000068 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
ADAM10 |
|
Synonyms |
AD10|CD156c|HsT18717|MADM|kuz |
|
Gene name |
ADAM metallopeptidase domain 10 |
|
Gene Type |
protein-coding |
|
Chromosome |
15 |
|
Genomics Location |
15q2|15q22 |
|
Known cancer genes |
Yes |
|
Protein products |
ADAM metallopeptidase domain 10, isoform CRA a Disintegrin and metalloproteinase domain-containing protein 10 |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:188
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0001701 |
in utero embryonic development |
|
GO:0004175 |
endopeptidase activity |
|
GO:0004222 |
metalloendopeptidase activity |
|
GO:0005102 |
receptor binding |
|
GO:0005178 |
integrin binding |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005794 |
Golgi apparatus |
|
GO:0005798 |
Golgi-associated vesicle |
|
GO:0005886 |
plasma membrane |
|
GO:0006468 |
protein phosphorylation |
|
GO:0006508 |
proteolysis |
|
GO:0006509 |
membrane protein ectodomain proteolysis |
|
GO:0007162 |
negative regulation of cell adhesion |
|
GO:0007173 |
epidermal growth factor receptor signaling pathway |
|
GO:0007219 |
Notch signaling pathway |
|
GO:0007220 |
Notch receptor processing |
|
GO:0007229 |
integrin-mediated signaling pathway |
|
GO:0007267 |
cell-cell signaling |
|
GO:0008233 |
peptidase activity |
|
GO:0008237 |
metallopeptidase activity |
|
GO:0008270 |
zinc ion binding |
|
GO:0008284 |
positive regulation of cell proliferation |
|
GO:0009986 |
cell surface |
|
GO:0010820 |
positive regulation of T cell chemotaxis |
|
GO:0012505 |
endomembrane system |
|
GO:0014069 |
postsynaptic density |
|
GO:0016021 |
integral to membrane |
|
GO:0017124 |
SH3 domain binding |
|
GO:0019901 |
protein kinase binding |
|
GO:0030307 |
positive regulation of cell growth |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0034612 |
response to tumor necrosis factor |
|
GO:0042117 |
monocyte activation |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0046872 |
metal ion binding |
|
GO:0051088 |
PMA-inducible membrane protein ectodomain proteolysis |
|
GO:0051089 |
constitutive protein ectodomain proteolysis |
