HuLG000069

Entrez Gene ID

103

Official Gene Symbol

ADAR

Synonyms

ADAR1|DRADA|DSH|DSRAD|G1P1|IFIN4|IFI4|K88DSRBP|P136

Gene name

adenosine deaminase, RNA-specific

Gene Type

protein-coding

Chromosome

1

Genomics Location

1q21.1-q21.2

Known cancer genes

Yes

Protein products

Truncated adenosine deaminase acting on RNA 1-A

Adenosine deaminase acting on RNA 1-A

Double-stranded RNA-specific adenosine deaminase

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Hepatocellular carcinoma

Liver fibrosis and liver cirrhosis caused by hepatitis C infection

Hepatocellular carcinoma

Database cross reference

HGNC:225
MIM:146920
Ensembl:ENSG00000160710
HPRD:07528
RefSeq Genomic nucleotide accession:AC_000044
RefSeq Genomic nucleotide gi:89161184

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0003677

DNA binding

GO:0003725

double-stranded RNA binding

GO:0003726

double-stranded RNA adenosine deaminase activity

GO:0005622

intracellular

GO:0005634

nucleus

GO:0005654

nucleoplasm

GO:0005730

nucleolus

GO:0005737

cytoplasm

GO:0006382

adenosine to inosine editing

GO:0006397

mRNA processing

GO:0016553

base conversion or substitution editing

GO:0016556

mRNA modification

GO:0016787

hydrolase activity

GO:0019221

cytokine-mediated signaling pathway

GO:0031047

gene silencing by RNA

GO:0043066

negative regulation of apoptosis

GO:0046872

metal ion binding

GO:0060337

type I interferon-mediated signaling pathway