HuLG000096

Entrez Gene ID

135

Official Gene Symbol

ADORA2A

Synonyms

ADORA2|RDC8|hA2aR

Gene name

adenosine A2a receptor

Gene Type

protein-coding

Chromosome

22

Genomics Location

22q11.23

Known cancer genes

Yes

Protein products

Adenosine receptor A2a

cDNA FLJ41063 fis, clone THYMU2013950, highly similar to ADENOSINE A2A RECEPTOR

Dombrock blood group carrier molecule

Dombrock blood group carrier molecule

Mono-ADP-ribosyltransferase 4

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:263
MIM:102776
Ensembl:ENSG00000100014
Ensembl:ENSG00000128271
HPRD:00043
RefSeq Genomic nucleotide accession:AC_000065
RefSeq Genomic nucleotide gi:89161202

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0001609

adenosine receptor activity, G-protein coupled

GO:0001963

synaptic transmission, dopaminergic

GO:0001975

response to amphetamine

GO:0004872

receptor activity

GO:0005515

protein binding

GO:0005624

membrane fraction

GO:0005882

intermediate filament

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0006171

cAMP biosynthetic process

GO:0006355

regulation of transcription, DNA-dependent

GO:0006469

negative regulation of protein kinase activity

GO:0006909

phagocytosis

GO:0006915

apoptosis

GO:0006954

inflammatory response

GO:0006968

cellular defense response

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO:0007188

G-protein signaling, coupled to cAMP nucleotide second messenger

GO:0007189

activation of adenylate cyclase activity by G-protein signaling pathway

GO:0007190

activation of adenylate cyclase activity

GO:0007205

activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

GO:0007267

cell-cell signaling

GO:0007271

synaptic transmission, cholinergic

GO:0007417

central nervous system development

GO:0007596

blood coagulation

GO:0007600

sensory perception

GO:0007626

locomotory behavior

GO:0008015

blood circulation

GO:0008285

negative regulation of cell proliferation

GO:0012505

endomembrane system

GO:0014049

positive regulation of glutamate secretion

GO:0014057

positive regulation of acetylcholine secretion

GO:0014061

regulation of norepinephrine secretion

GO:0014069

postsynaptic density

GO:0019899

enzyme binding

GO:0030424

axon

GO:0030425

dendrite

GO:0030673

axolemma

GO:0030819

positive regulation of cAMP biosynthetic process

GO:0031000

response to caffeine

GO:0031558

induction of apoptosis in response to chemical stimulus

GO:0031802

type 5 metabotropic glutamate receptor binding

GO:0032230

positive regulation of synaptic transmission, GABAergic

GO:0032279

asymmetric synapse

GO:0040013

negative regulation of locomotion

GO:0042311

vasodilation

GO:0042734

presynaptic membrane

GO:0042755

eating behavior

GO:0043025

neuronal cell body

GO:0043116

negative regulation of vascular permeability

GO:0043154

negative regulation of caspase activity

GO:0043524

negative regulation of neuron apoptosis

GO:0044446

intracellular organelle part

GO:0045211

postsynaptic membrane

GO:0046636

negative regulation of alpha-beta T cell activation

GO:0046982

protein heterodimerization activity

GO:0048011

nerve growth factor receptor signaling pathway

GO:0048143

astrocyte activation

GO:0048167

regulation of synaptic plasticity

GO:0048786

presynaptic active zone

GO:0048812

neuron projection morphogenesis

GO:0050714

positive regulation of protein secretion

GO:0050728

negative regulation of inflammatory response

GO:0051372

nonmuscle alpha-actinin binding

GO:0051881

regulation of mitochondrial membrane potential

GO:0051925

regulation of calcium ion transport via voltage-gated calcium channel activity

GO:0051968

positive regulation of synaptic transmission, glutamatergic

GO:0060079

regulation of excitatory postsynaptic membrane potential

GO:0060080

regulation of inhibitory postsynaptic membrane potential

GO:0060134

prepulse inhibition