HuLG000100

Entrez Gene ID

142

Official Gene Symbol

PARP1

Synonyms

ADPRT|ADPRT_1|ADPRT1|PARP|PARPN1|PPOL|pADPRTN1

Gene name

poly (ADP-ribose) polymerase 1

Gene Type

protein-coding

Chromosome

1

Genomics Location

1q41-q42

Known cancer genes

Yes

Protein products

Poly [ADP-ribose] polymerase 1

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Database cross reference

HGNC:270
MIM:173870
Ensembl:ENSG00000143799
HPRD:01435
RefSeq Genomic nucleotide accession:AC_000044
RefSeq Genomic nucleotide gi:89161184

HCC significant genes

Yes/No

Yes

Evidence

EHCO OncoDB

Quality score

GO annotation

GO:0000723

telomere maintenance

GO:0003677

DNA binding

GO:0003950

NAD+ ADP-ribosyltransferase activity

GO:0005515

protein binding

GO:0005622

intracellular

GO:0005634

nucleus

GO:0005635

nuclear envelope

GO:0005654

nucleoplasm

GO:0005667

transcription factor complex

GO:0005730

nucleolus

GO:0006281

DNA repair

GO:0006284

base-excision repair

GO:0006355

regulation of transcription, DNA-dependent

GO:0006366

transcription from RNA polymerase II promoter

GO:0006471

protein ADP-ribosylation

GO:0008134

transcription factor binding

GO:0008270

zinc ion binding

GO:0016540

protein autoprocessing

GO:0016757

transferase activity, transferring glycosyl groups

GO:0032869

cellular response to insulin stimulus

GO:0040009

regulation of growth rate

GO:0042769

DNA damage response, detection of DNA damage

GO:0042802

identical protein binding

GO:0046872

metal ion binding

GO:0047485

protein N-terminus binding

GO:0051287

NAD binding