Gene basic information
| LiverAtlas Gene ID |
HuLG000146 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
AKT1 |
|
Synonyms |
AKT|MGC99656|PKB|PKBNALPHA|PRKBA|RAC|RACNALPHA |
|
Gene name |
v-akt murine thymoma viral oncogene homolog 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
14 |
|
Genomics Location |
14q32.32|14q32.32 |
|
Known cancer genes |
Yes |
|
Protein products |
RAC-alpha serine/threonine-protein kinase |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:391
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000060 |
protein import into nucleus, translocation |
|
GO:0000166 |
nucleotide binding |
|
GO:0001649 |
osteoblast differentiation |
|
GO:0001893 |
maternal placenta development |
|
GO:0001934 |
positive regulation of protein phosphorylation |
|
GO:0004672 |
protein kinase activity |
|
GO:0004674 |
protein serine/threonine kinase activity |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005547 |
phosphatidylinositol-3,4,5-trisphosphate binding |
|
GO:0005625 |
soluble fraction |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005737 |
cytoplasm |
|
GO:0005819 |
spindle |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0005975 |
carbohydrate metabolic process |
|
GO:0005979 |
regulation of glycogen biosynthetic process |
|
GO:0006417 |
regulation of translation |
|
GO:0006464 |
protein modification process |
|
GO:0006468 |
protein phosphorylation |
|
GO:0006469 |
negative regulation of protein kinase activity |
|
GO:0006809 |
nitric oxide biosynthetic process |
|
GO:0006810 |
transport |
|
GO:0006915 |
apoptosis |
|
GO:0006916 |
anti-apoptosis |
|
GO:0006924 |
activation-induced cell death of T cells |
|
GO:0006954 |
inflammatory response |
|
GO:0007165 |
signal transduction |
|
GO:0007186 |
G-protein coupled receptor protein signaling pathway |
|
GO:0007281 |
germ cell development |
|
GO:0007399 |
nervous system development |
|
GO:0007596 |
blood coagulation |
|
GO:0008286 |
insulin receptor signaling pathway |
|
GO:0008629 |
induction of apoptosis by intracellular signals |
|
GO:0008633 |
activation of pro-apoptotic gene products |
|
GO:0008637 |
apoptotic mitochondrial changes |
|
GO:0008643 |
carbohydrate transport |
|
GO:0009408 |
response to heat |
|
GO:0009725 |
response to hormone stimulus |
|
GO:0010748 |
negative regulation of plasma membrane long-chain fatty acid transport |
|
GO:0010765 |
positive regulation of sodium ion transport |
|
GO:0010907 |
positive regulation of glucose metabolic process |
|
GO:0010975 |
regulation of neuron projection development |
|
GO:0015630 |
microtubule cytoskeleton |
|
GO:0015758 |
glucose transport |
|
GO:0016070 |
RNA metabolic process |
|
GO:0016071 |
mRNA metabolic process |
|
GO:0016301 |
kinase activity |
|
GO:0016310 |
phosphorylation |
|
GO:0016567 |
protein ubiquitination |
|
GO:0018105 |
peptidyl-serine phosphorylation |
|
GO:0019899 |
enzyme binding |
|
GO:0030027 |
lamellipodium |
|
GO:0030030 |
cell projection organization |
|
GO:0030163 |
protein catabolic process |
|
GO:0030168 |
platelet activation |
|
GO:0030235 |
nitric-oxide synthase regulator activity |
|
GO:0030307 |
positive regulation of cell growth |
|
GO:0030334 |
regulation of cell migration |
|
GO:0031018 |
endocrine pancreas development |
|
GO:0031295 |
T cell costimulation |
|
GO:0031659 |
positive regulation of cyclin-dependent protein kinase activity involved in G1/S |
|
GO:0031999 |
negative regulation of fatty acid beta-oxidation |
|
GO:0032094 |
response to food |
|
GO:0032270 |
positive regulation of cellular protein metabolic process |
|
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
|
GO:0032869 |
cellular response to insulin stimulus |
|
GO:0032880 |
regulation of protein localization |
|
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
|
GO:0034405 |
response to fluid shear stress |
|
GO:0035556 |
intracellular signal transduction |
|
GO:0042593 |
glucose homeostasis |
|
GO:0042640 |
anagen |
|
GO:0042802 |
identical protein binding |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043325 |
phosphatidylinositol-3,4-bisphosphate binding |
|
GO:0043491 |
protein kinase B signaling cascade |
|
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
|
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
|
GO:0045600 |
positive regulation of fat cell differentiation |
|
GO:0045725 |
positive regulation of glycogen biosynthetic process |
|
GO:0045792 |
negative regulation of cell size |
|
GO:0045884 |
regulation of survival gene product expression |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046209 |
nitric oxide metabolic process |
|
GO:0046326 |
positive regulation of glucose import |
|
GO:0046329 |
negative regulation of JNK cascade |
|
GO:0046777 |
protein autophosphorylation |
|
GO:0046889 |
positive regulation of lipid biosynthetic process |
|
GO:0048009 |
insulin-like growth factor receptor signaling pathway |
|
GO:0048011 |
nerve growth factor receptor signaling pathway |
|
GO:0048015 |
phosphatidylinositol-mediated signaling |
|
GO:0050999 |
regulation of nitric-oxide synthase activity |
|
GO:0051000 |
positive regulation of nitric-oxide synthase activity |
|
GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
|
GO:0051146 |
striated muscle cell differentiation |
|
GO:0060709 |
glycogen cell development involved in embryonic placenta development |
|
GO:0060716 |
labyrinthine layer blood vessel development |
|
GO:0070141 |
response to UV-A |
|
GO:0071363 |
cellular response to growth factor stimulus |
|
GO:0090004 |
positive regulation of establishment of protein localization in plasma membrane |
