Gene basic information
| LiverAtlas Gene ID |
HuLG000232 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
APC |
|
Synonyms |
BTPS2|DP2|DP2.5|DP3|GS |
|
Gene name |
adenomatous polyposis coli |
|
Gene Type |
protein-coding |
|
Chromosome |
5 |
|
Genomics Location |
5q21-q22 |
|
Known cancer genes |
Yes |
|
Protein products |
Adenomatous polyposis coli protein cDNA FLJ50140, highly similar to Adenomatous polyposis coli protein Adenomatous polyposis coli protein Adenomatous polyposis coli protein |
|
Related liver disease name |
Liver fibrosis and liver cirrhosis |
|
Database cross reference |
HGNC:583
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000281 |
cytokinesis after mitosis |
|
GO:0000776 |
kinetochore |
|
GO:0001822 |
kidney development |
|
GO:0001942 |
hair follicle development |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005813 |
centrosome |
|
GO:0005829 |
cytosol |
|
GO:0005856 |
cytoskeleton |
|
GO:0005881 |
cytoplasmic microtubule |
|
GO:0005886 |
plasma membrane |
|
GO:0005913 |
cell-cell adherens junction |
|
GO:0005923 |
tight junction |
|
GO:0006461 |
protein complex assembly |
|
GO:0006915 |
apoptosis |
|
GO:0006921 |
cellular component disassembly involved in apoptosis |
|
GO:0006974 |
response to DNA damage stimulus |
|
GO:0007026 |
negative regulation of microtubule depolymerization |
|
GO:0007050 |
cell cycle arrest |
|
GO:0007091 |
mitotic metaphase/anaphase transition |
|
GO:0007094 |
mitotic cell cycle spindle assembly checkpoint |
|
GO:0007155 |
cell adhesion |
|
GO:0007163 |
establishment or maintenance of cell polarity |
|
GO:0007409 |
axonogenesis |
|
GO:0008013 |
beta-catenin binding |
|
GO:0008017 |
microtubule binding |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0009798 |
axis specification |
|
GO:0009952 |
anterior/posterior pattern formation |
|
GO:0009953 |
dorsal/ventral pattern formation |
|
GO:0009954 |
proximal/distal pattern formation |
|
GO:0016328 |
lateral plasma membrane |
|
GO:0016477 |
cell migration |
|
GO:0019887 |
protein kinase regulator activity |
|
GO:0019901 |
protein kinase binding |
|
GO:0030027 |
lamellipodium |
|
GO:0030054 |
cell junction |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0030858 |
positive regulation of epithelial cell differentiation |
|
GO:0030877 |
beta-catenin destruction complex |
|
GO:0031016 |
pancreas development |
|
GO:0031116 |
positive regulation of microtubule polymerization |
|
GO:0031122 |
cytoplasmic microtubule organization |
|
GO:0031175 |
neuron projection development |
|
GO:0031274 |
positive regulation of pseudopodium assembly |
|
GO:0032587 |
ruffle membrane |
|
GO:0032886 |
regulation of microtubule-based process |
|
GO:0033077 |
T cell differentiation in thymus |
|
GO:0034742 |
APC-Axin-1-beta-catenin complex |
|
GO:0034747 |
Axin-APC-beta-catenin-GSK3B complex |
|
GO:0034750 |
Scrib-APC-beta-catenin complex |
|
GO:0035019 |
somatic stem cell maintenance |
|
GO:0035371 |
microtubule plus end |
|
GO:0042483 |
negative regulation of odontogenesis |
|
GO:0042493 |
response to drug |
|
GO:0043025 |
neuronal cell body |
|
GO:0043065 |
positive regulation of apoptosis |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043409 |
negative regulation of MAPKKK cascade |
|
GO:0043588 |
skin development |
|
GO:0044295 |
axonal growth cone |
|
GO:0045202 |
synapse |
|
GO:0045295 |
gamma-catenin binding |
|
GO:0045296 |
cadherin binding |
|
GO:0045667 |
regulation of osteoblast differentiation |
|
GO:0045670 |
regulation of osteoclast differentiation |
|
GO:0045732 |
positive regulation of protein catabolic process |
|
GO:0045736 |
negative regulation of cyclin-dependent protein kinase activity |
|
GO:0045785 |
positive regulation of cell adhesion |
|
GO:0046716 |
muscle cell homeostasis |
|
GO:0048538 |
thymus development |
|
GO:0051010 |
microtubule plus-end binding |
|
GO:0051171 |
regulation of nitrogen compound metabolic process |
|
GO:0051276 |
chromosome organization |
|
GO:0051726 |
regulation of cell cycle |
|
GO:0051781 |
positive regulation of cell division |
|
GO:0051988 |
regulation of attachment of spindle microtubules to kinetochore |
|
GO:0060041 |
retina development in camera-type eye |
|
GO:0060070 |
canonical Wnt receptor signaling pathway |
|
GO:0060770 |
negative regulation of epithelial cell proliferation involved in prostate gland development |
|
GO:0070830 |
tight junction assembly |
|
GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
