Gene basic information
| LiverAtlas Gene ID |
HuLG000236 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
APEX1 |
|
Synonyms |
APE|APE1|APEN|APEX|APX|HAP1|REF1 |
|
Gene name |
APEX nuclease (multifunctional DNA repair enzyme) 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
14 |
|
Genomics Location |
14q11.2 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:587
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0003677 |
DNA binding |
|
GO:0003684 |
damaged DNA binding |
|
GO:0003713 |
transcription coactivator activity |
|
GO:0003714 |
transcription corepressor activity |
|
GO:0003723 |
RNA binding |
|
GO:0003906 |
DNA-(apurinic or apyrimidinic site) lyase activity |
|
GO:0004519 |
endonuclease activity |
|
GO:0004520 |
endodeoxyribonuclease activity |
|
GO:0004523 |
ribonuclease H activity |
|
GO:0004528 |
phosphodiesterase I activity |
|
GO:0004844 |
uracil DNA N-glycosylase activity |
|
GO:0005515 |
protein binding |
|
GO:0005622 |
intracellular |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005730 |
nucleolus |
|
GO:0005737 |
cytoplasm |
|
GO:0005739 |
mitochondrion |
|
GO:0005783 |
endoplasmic reticulum |
|
GO:0005813 |
centrosome |
|
GO:0005840 |
ribosome |
|
GO:0006281 |
DNA repair |
|
GO:0006284 |
base-excision repair |
|
GO:0006310 |
DNA recombination |
|
GO:0006355 |
regulation of transcription, DNA-dependent |
|
GO:0008081 |
phosphoric diester hydrolase activity |
|
GO:0008408 |
3'-5' exonuclease activity |
|
GO:0016491 |
oxidoreductase activity |
|
GO:0016607 |
nuclear speck |
|
GO:0016787 |
hydrolase activity |
|
GO:0016829 |
lyase activity |
|
GO:0016890 |
site-specific endodeoxyribonuclease activity, specific for altered base |
|
GO:0031490 |
chromatin DNA binding |
|
GO:0043488 |
regulation of mRNA stability |
|
GO:0045454 |
cell redox homeostasis |
|
GO:0045739 |
positive regulation of DNA repair |
|
GO:0045768 |
positive regulation of anti-apoptosis |
|
GO:0046872 |
metal ion binding |
|
GO:0048471 |
perinuclear region of cytoplasm |
|
GO:0055114 |
oxidation-reduction process |
