Gene basic information
| LiverAtlas Gene ID |
HuLG000254 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
APOE |
|
Synonyms |
AD2|LDLCQ5|LPG|MGC1571 |
|
Gene name |
apolipoprotein E |
|
Gene Type |
protein-coding |
|
Chromosome |
19 |
|
Genomics Location |
19q13.2 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
Liver fibrosis and liver cirrhosis Liver fibrosis and liver cirrhosis caused by hepatitis C infection |
|
Database cross reference |
HGNC:613
|
Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
|
Evidence |
Translational level from literatures |
|
|
Quality score |
|
|
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000302 |
response to reactive oxygen species |
|
GO:0001540 |
beta-amyloid binding |
|
GO:0001937 |
negative regulation of endothelial cell proliferation |
|
GO:0002021 |
response to dietary excess |
|
GO:0005319 |
lipid transporter activity |
|
GO:0005515 |
protein binding |
|
GO:0005543 |
phospholipid binding |
|
GO:0005576 |
extracellular region |
|
GO:0005615 |
extracellular space |
|
GO:0005737 |
cytoplasm |
|
GO:0005769 |
early endosome |
|
GO:0005770 |
late endosome |
|
GO:0005794 |
Golgi apparatus |
|
GO:0005874 |
microtubule |
|
GO:0005886 |
plasma membrane |
|
GO:0006629 |
lipid metabolic process |
|
GO:0006641 |
triglyceride metabolic process |
|
GO:0006707 |
cholesterol catabolic process |
|
GO:0006874 |
cellular calcium ion homeostasis |
|
GO:0006898 |
receptor-mediated endocytosis |
|
GO:0006916 |
anti-apoptosis |
|
GO:0006917 |
induction of apoptosis |
|
GO:0007010 |
cytoskeleton organization |
|
GO:0007186 |
G-protein coupled receptor protein signaling pathway |
|
GO:0007263 |
nitric oxide mediated signal transduction |
|
GO:0007271 |
synaptic transmission, cholinergic |
|
GO:0007568 |
aging |
|
GO:0008201 |
heparin binding |
|
GO:0008203 |
cholesterol metabolic process |
|
GO:0008219 |
cell death |
|
GO:0008289 |
lipid binding |
|
GO:0010468 |
regulation of gene expression |
|
GO:0010544 |
negative regulation of platelet activation |
|
GO:0010873 |
positive regulation of cholesterol esterification |
|
GO:0010875 |
positive regulation of cholesterol efflux |
|
GO:0014012 |
peripheral nervous system axon regeneration |
|
GO:0016209 |
antioxidant activity |
|
GO:0017127 |
cholesterol transporter activity |
|
GO:0019934 |
cGMP-mediated signaling |
|
GO:0030195 |
negative regulation of blood coagulation |
|
GO:0030425 |
dendrite |
|
GO:0030516 |
regulation of axon extension |
|
GO:0030828 |
positive regulation of cGMP biosynthetic process |
|
GO:0031232 |
extrinsic to external side of plasma membrane |
|
GO:0032488 |
Cdc42 protein signal transduction |
|
GO:0032805 |
positive regulation of low-density lipoprotein particle receptor catabolic process |
|
GO:0033344 |
cholesterol efflux |
|
GO:0033700 |
phospholipid efflux |
|
GO:0034361 |
very-low-density lipoprotein particle |
|
GO:0034362 |
low-density lipoprotein particle |
|
GO:0034363 |
intermediate-density lipoprotein particle |
|
GO:0034364 |
high-density lipoprotein particle |
|
GO:0034372 |
very-low-density lipoprotein particle remodeling |
|
GO:0034374 |
low-density lipoprotein particle remodeling |
|
GO:0034375 |
high-density lipoprotein particle remodeling |
|
GO:0034380 |
high-density lipoprotein particle assembly |
|
GO:0034382 |
chylomicron remnant clearance |
|
GO:0034384 |
high-density lipoprotein particle clearance |
|
GO:0034447 |
very-low-density lipoprotein particle clearance |
|
GO:0042157 |
lipoprotein metabolic process |
|
GO:0042158 |
lipoprotein biosynthetic process |
|
GO:0042159 |
lipoprotein catabolic process |
|
GO:0042311 |
vasodilation |
|
GO:0042627 |
chylomicron |
|
GO:0042632 |
cholesterol homeostasis |
|
GO:0042802 |
identical protein binding |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0043025 |
neuronal cell body |
|
GO:0043407 |
negative regulation of MAP kinase activity |
|
GO:0043537 |
negative regulation of blood vessel endothelial cell migration |
|
GO:0043691 |
reverse cholesterol transport |
|
GO:0045471 |
response to ethanol |
|
GO:0045541 |
negative regulation of cholesterol biosynthetic process |
|
GO:0046907 |
intracellular transport |
|
GO:0046911 |
metal chelating activity |
|
GO:0046982 |
protein heterodimerization activity |
|
GO:0048156 |
tau protein binding |
|
GO:0048168 |
regulation of neuronal synaptic plasticity |
|
GO:0048844 |
artery morphogenesis |
|
GO:0050728 |
negative regulation of inflammatory response |
|
GO:0050750 |
low-density lipoprotein particle receptor binding |
|
GO:0051000 |
positive regulation of nitric-oxide synthase activity |
|
GO:0051044 |
positive regulation of membrane protein ectodomain proteolysis |
|
GO:0051651 |
maintenance of location in cell |
|
GO:0055088 |
lipid homeostasis |
|
GO:0060228 |
phosphatidylcholine-sterol O-acyltransferase activator activity |
|
GO:0070326 |
very-low-density lipoprotein particle receptor binding |
|
GO:0071363 |
cellular response to growth factor stimulus |
|
GO:0071813 |
lipoprotein particle binding |
