HuLG000256

Entrez Gene ID

351

Official Gene Symbol

APP

Synonyms

AAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN2

Gene name

amyloid beta (A4) precursor protein

Gene Type

protein-coding

Chromosome

21

Genomics Location

21q21.2|21q21.3

Known cancer genes

Yes

Protein products

Amyloid beta A4 protein

cDNA FLJ50491, highly similar to Amyloid beta A4 protein (APP) (ABPP)(Alzheimer disease amyloid protein) (Cerebral vascularamylo

Uncharacterized protein

Amyloid beta protein

Related liver disease name

Hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Database cross reference

HGNC:620
MIM:104760
Ensembl:ENSG00000142192
HPRD:00100
RefSeq Genomic nucleotide accession:AC_000064
RefSeq Genomic nucleotide gi:89161201

HCC significant genes

Yes/No

Yes

Evidence

HCC.net

Quality score

GO annotation

GO:0000085

G2 phase of mitotic cell cycle

GO:0001967

suckling behavior

GO:0002576

platelet degranulation

GO:0003677

DNA binding

GO:0004867

serine-type endopeptidase inhibitor activity

GO:0005102

receptor binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005737

cytoplasm

GO:0005794

Golgi apparatus

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0005905

coated pit

GO:0006378

mRNA polyadenylation

GO:0006417

regulation of translation

GO:0006468

protein phosphorylation

GO:0006878

cellular copper ion homeostasis

GO:0006897

endocytosis

GO:0006917

induction of apoptosis

GO:0007155

cell adhesion

GO:0007176

regulation of epidermal growth factor receptor activity

GO:0007219

Notch signaling pathway

GO:0007409

axonogenesis

GO:0007596

blood coagulation

GO:0007617

mating behavior

GO:0007626

locomotory behavior

GO:0008088

axon cargo transport

GO:0008201

heparin binding

GO:0008219

cell death

GO:0008344

adult locomotory behavior

GO:0008542

visual learning

GO:0009986

cell surface

GO:0016021

integral to membrane

GO:0016199

axon midline choice point recognition

GO:0016322

neuron remodeling

GO:0016358

dendrite development

GO:0016504

peptidase activator activity

GO:0019717

synaptosome

GO:0030168

platelet activation

GO:0030198

extracellular matrix organization

GO:0030414

peptidase inhibitor activity

GO:0030424

axon

GO:0030900

forebrain development

GO:0031093

platelet alpha granule lumen

GO:0031175

neuron projection development

GO:0031410

cytoplasmic vesicle

GO:0031594

neuromuscular junction

GO:0033130

acetylcholine receptor binding

GO:0035235

ionotropic glutamate receptor signaling pathway

GO:0035253

ciliary rootlet

GO:0040014

regulation of multicellular organism growth

GO:0042802

identical protein binding

GO:0043197

dendritic spine

GO:0043198

dendritic shaft

GO:0043231

intracellular membrane-bounded organelle

GO:0045087

innate immune response

GO:0045177

apical part of cell

GO:0045202

synapse

GO:0045665

negative regulation of neuron differentiation

GO:0045931

positive regulation of mitotic cell cycle

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0046872

metal ion binding

GO:0048471

perinuclear region of cytoplasm

GO:0048669

collateral sprouting in absence of injury

GO:0050803

regulation of synapse structure and activity

GO:0050885

neuromuscular process controlling balance

GO:0051124

synaptic growth at neuromuscular junction

GO:0051233

spindle midzone

GO:0051402

neuron apoptosis

GO:0051425

PTB domain binding

GO:0051563

smooth endoplasmic reticulum calcium ion homeostasis