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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG000259

Entrez Gene ID

355

Official Gene Symbol

FAS

Synonyms

ALPS1A|APON1|APT1|CD95|FAS1|FASTM|TNFRSF6

Gene name

Fas (TNF receptor superfamily, member 6)

Gene Type

protein-coding

Chromosome

10

Genomics Location

10q24.1

Known cancer genes

Yes

Protein products

FAS variant

Fas (TNF receptor superfamily, member 6)

TNFRSF6 protein

CD95 antigen

CD95 antigen

Tumor necrosis factor receptor superfamily member 6

Related liver disease name

Hepatitis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Autoimmune hepatitis

Hepatocellular carcinoma

Primary biliary cirrhosis

Autoimmune hepatitis

Intrahepatic cholangiocarcinoma

Hepatocellular carcinoma

Primary sclerosing cholangitis

Database cross reference

HGNC:11920
MIM:134637
Ensembl:ENSG00000026103
HPRD:00609
RefSeq Genomic nucleotide accession:AC_000053
RefSeq Genomic nucleotide gi:89161186

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net OncoDB

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001666

response to hypoxia

GO:0002377

immunoglobulin production

GO:0003014

renal system process

GO:0004871

signal transducer activity

GO:0004872

receptor activity

GO:0004888

transmembrane receptor activity

GO:0005031

tumor necrosis factor receptor activity

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005625

soluble fraction

GO:0005829

cytosol

GO:0005886

plasma membrane

GO:0005901

caveola

GO:0006461

protein complex assembly

GO:0006915

apoptosis

GO:0006916

anti-apoptosis

GO:0006917

induction of apoptosis

GO:0006919

activation of caspase activity

GO:0006924

activation-induced cell death of T cells

GO:0006925

inflammatory cell apoptosis

GO:0006927

transformed cell apoptosis

GO:0006955

immune response

GO:0007165

signal transduction

GO:0007283

spermatogenesis

GO:0007568

aging

GO:0008624

induction of apoptosis by extracellular signals

GO:0008625

induction of apoptosis via death domain receptors

GO:0008633

activation of pro-apoptotic gene products

GO:0009636

response to toxin

GO:0009897

external side of plasma membrane

GO:0010035

response to inorganic substance

GO:0010467

gene expression

GO:0010940

positive regulation of necrotic cell death

GO:0016021

integral to membrane

GO:0019724

B cell mediated immunity

GO:0019900

kinase binding

GO:0031104

dendrite regeneration

GO:0031264

death-inducing signaling complex

GO:0031265

CD95 death-inducing signaling complex

GO:0032496

response to lipopolysaccharide

GO:0034097

response to cytokine stimulus

GO:0042127

regulation of cell proliferation

GO:0042493

response to drug

GO:0042698

ovulation cycle

GO:0042802

identical protein binding

GO:0042981

regulation of apoptosis

GO:0043434

response to peptide hormone stimulus

GO:0043627

response to estrogen stimulus

GO:0045060

negative thymic T cell selection

GO:0045619

regulation of lymphocyte differentiation

GO:0045637

regulation of myeloid cell differentiation

GO:0048471

perinuclear region of cytoplasm

GO:0048536

spleen development

GO:0050869

negative regulation of B cell activation

GO:0051260

protein homooligomerization

GO:0051384

response to glucocorticoid stimulus

GO:0051402

neuron apoptosis

GO:0051789

response to protein stimulus

GO:0070848

response to growth factor stimulus

GO:0071260

cellular response to mechanical stimulus

GO:0071285

cellular response to lithium ion