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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG000316

Entrez Gene ID

429

Official Gene Symbol

ASCL1

Synonyms

ASH1|HASH1|MASH1|bHLHa46

Gene name

achaete-scute complex homolog 1 (Drosophila)

Gene Type

protein-coding

Chromosome

12

Genomics Location

12q23.2

Known cancer genes

Yes

Protein products

Achaete-scute homolog 1

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:738
MIM:100790
Ensembl:ENSG00000139352
HPRD:00011
RefSeq Genomic nucleotide accession:AC_000055
RefSeq Genomic nucleotide gi:89161189

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001764

neuron migration

GO:0003359

noradrenergic neuron fate commitment

GO:0003690

double-stranded DNA binding

GO:0003700

sequence-specific DNA binding transcription factor activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0006351

transcription, DNA-dependent

GO:0007219

Notch signaling pathway

GO:0007389

pattern specification process

GO:0007400

neuroblast fate determination

GO:0007405

neuroblast proliferation

GO:0010226

response to lithium ion

GO:0014003

oligodendrocyte development

GO:0021527

spinal cord association neuron differentiation

GO:0021530

spinal cord oligodendrocyte cell fate specification

GO:0021779

oligodendrocyte cell fate commitment

GO:0021879

forebrain neuron differentiation

GO:0021892

cerebral cortex GABAergic interneuron differentiation

GO:0021954

central nervous system neuron development

GO:0021987

cerebral cortex development

GO:0022008

neurogenesis

GO:0032526

response to retinoic acid

GO:0042803

protein homodimerization activity

GO:0043025

neuronal cell body

GO:0043066

negative regulation of apoptosis

GO:0043425

bHLH transcription factor binding

GO:0043525

positive regulation of neuron apoptosis

GO:0043565

sequence-specific DNA binding

GO:0045665

negative regulation of neuron differentiation

GO:0045666

positive regulation of neuron differentiation

GO:0045747

positive regulation of Notch signaling pathway

GO:0045892

negative regulation of transcription, DNA-dependent

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0048485

sympathetic nervous system development

GO:0048665

neuron fate specification

GO:0050769

positive regulation of neurogenesis

GO:0051593

response to folic acid

GO:0060163

subpallium neuron fate commitment

GO:0060165

regulation of timing of subpallium neuron differentiation

GO:0060166

olfactory pit development

GO:0060487

lung epithelial cell differentiation

GO:0061100

lung neuroendocrine cell differentiation

GO:0061102

stomach neuroendocrine cell differentiation

GO:0061103

carotid body glomus cell differentiation

GO:0061104

adrenal chromaffin cell differentiation

GO:0070849

response to epidermal growth factor stimulus

GO:0070888

E-box binding

GO:0071259

cellular response to magnetism