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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG000333

Entrez Gene ID

468

Official Gene Symbol

ATF4

Synonyms

CREBN2|CREB2|TAXREB67|TXREB

Gene name

activating transcription factor 4 (tax-responsive enhancer element B67)

Gene Type

protein-coding

Chromosome

22

Genomics Location

22q13.1

Known cancer genes

Yes

Protein products

Cyclic AMP-dependent transcription factor ATF-4

ATF4 protein

ATF4 protein

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:786
MIM:604064
Ensembl:ENSG00000128272
HPRD:06817
RefSeq Genomic nucleotide accession:AC_000065
RefSeq Genomic nucleotide gi:89161202

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0003677

DNA binding

GO:0003700

sequence-specific DNA binding transcription factor activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005667

transcription factor complex

GO:0005737

cytoplasm

GO:0005886

plasma membrane

GO:0006094

gluconeogenesis

GO:0006351

transcription, DNA-dependent

GO:0006355

regulation of transcription, DNA-dependent

GO:0006520

cellular amino acid metabolic process

GO:0006950

response to stress

GO:0034976

response to endoplasmic reticulum stress

GO:0043565

sequence-specific DNA binding

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0046983

protein dimerization activity