Gene basic information
| LiverAtlas Gene ID |
HuLG000416 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
BCL2 |
|
Synonyms |
BclN2 |
|
Gene name |
B-cell CLL/lymphoma 2 |
|
Gene Type |
protein-coding |
|
Chromosome |
18 |
|
Genomics Location |
18q21.33|18q21.3 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
Liver fibrosis and liver cirrhosis |
|
Database cross reference |
HGNC:990
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000082 |
G1/S transition of mitotic cell cycle |
|
GO:0000209 |
protein polyubiquitination |
|
GO:0000902 |
cell morphogenesis |
|
GO:0001541 |
ovarian follicle development |
|
GO:0001656 |
metanephros development |
|
GO:0001657 |
ureteric bud development |
|
GO:0001658 |
branching involved in ureteric bud morphogenesis |
|
GO:0001662 |
behavioral fear response |
|
GO:0001666 |
response to hypoxia |
|
GO:0001782 |
B cell homeostasis |
|
GO:0001836 |
release of cytochrome c from mitochondria |
|
GO:0001952 |
regulation of cell-matrix adhesion |
|
GO:0002020 |
protease binding |
|
GO:0002320 |
lymphoid progenitor cell differentiation |
|
GO:0002326 |
B cell lineage commitment |
|
GO:0002360 |
T cell lineage commitment |
|
GO:0002520 |
immune system development |
|
GO:0003014 |
renal system process |
|
GO:0005515 |
protein binding |
|
GO:0005622 |
intracellular |
|
GO:0005624 |
membrane fraction |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005739 |
mitochondrion |
|
GO:0005741 |
mitochondrial outer membrane |
|
GO:0005783 |
endoplasmic reticulum |
|
GO:0005789 |
endoplasmic reticulum membrane |
|
GO:0005792 |
microsome |
|
GO:0005829 |
cytosol |
|
GO:0006470 |
protein dephosphorylation |
|
GO:0006582 |
melanin metabolic process |
|
GO:0006808 |
regulation of nitrogen utilization |
|
GO:0006915 |
apoptosis |
|
GO:0006916 |
anti-apoptosis |
|
GO:0006959 |
humoral immune response |
|
GO:0006974 |
response to DNA damage stimulus |
|
GO:0006979 |
response to oxidative stress |
|
GO:0007015 |
actin filament organization |
|
GO:0007565 |
female pregnancy |
|
GO:0007569 |
cell aging |
|
GO:0007584 |
response to nutrient |
|
GO:0008134 |
transcription factor binding |
|
GO:0008219 |
cell death |
|
GO:0008284 |
positive regulation of cell proliferation |
|
GO:0008584 |
male gonad development |
|
GO:0008629 |
induction of apoptosis by intracellular signals |
|
GO:0008633 |
activation of pro-apoptotic gene products |
|
GO:0009314 |
response to radiation |
|
GO:0009408 |
response to heat |
|
GO:0009605 |
response to external stimulus |
|
GO:0009636 |
response to toxin |
|
GO:0009791 |
post-embryonic development |
|
GO:0009887 |
organ morphogenesis |
|
GO:0010035 |
response to inorganic substance |
|
GO:0010039 |
response to iron ion |
|
GO:0010044 |
response to aluminum ion |
|
GO:0010224 |
response to UV-B |
|
GO:0010332 |
response to gamma radiation |
|
GO:0010468 |
regulation of gene expression |
|
GO:0010523 |
negative regulation of calcium ion transport into cytosol |
|
GO:0010559 |
regulation of glycoprotein biosynthetic process |
|
GO:0014031 |
mesenchymal cell development |
|
GO:0014042 |
positive regulation of neuron maturation |
|
GO:0014911 |
positive regulation of smooth muscle cell migration |
|
GO:0015267 |
channel activity |
|
GO:0016020 |
membrane |
|
GO:0016337 |
cell-cell adhesion |
|
GO:0018107 |
peptidyl-threonine phosphorylation |
|
GO:0021747 |
cochlear nucleus development |
|
GO:0022612 |
gland morphogenesis |
|
GO:0022898 |
regulation of transmembrane transporter activity |
|
GO:0030097 |
hemopoiesis |
|
GO:0030279 |
negative regulation of ossification |
|
GO:0030307 |
positive regulation of cell growth |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0030336 |
negative regulation of cell migration |
|
GO:0030890 |
positive regulation of B cell proliferation |
|
GO:0031000 |
response to caffeine |
|
GO:0031069 |
hair follicle morphogenesis |
|
GO:0031103 |
axon regeneration |
|
GO:0031647 |
regulation of protein stability |
|
GO:0031965 |
nuclear membrane |
|
GO:0032469 |
endoplasmic reticulum calcium ion homeostasis |
|
GO:0032835 |
glomerulus development |
|
GO:0032848 |
negative regulation of cellular pH reduction |
|
GO:0032868 |
response to insulin stimulus |
|
GO:0032880 |
regulation of protein localization |
|
GO:0033033 |
negative regulation of myeloid cell apoptosis |
|
GO:0033077 |
T cell differentiation in thymus |
|
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
|
GO:0033591 |
response to L-ascorbic acid |
|
GO:0033689 |
negative regulation of osteoblast proliferation |
|
GO:0034097 |
response to cytokine stimulus |
|
GO:0034349 |
glial cell apoptosis |
|
GO:0035094 |
response to nicotine |
|
GO:0035265 |
organ growth |
|
GO:0040018 |
positive regulation of multicellular organism growth |
|
GO:0042100 |
B cell proliferation |
|
GO:0042493 |
response to drug |
|
GO:0042542 |
response to hydrogen peroxide |
|
GO:0042802 |
identical protein binding |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0043029 |
T cell homeostasis |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043085 |
positive regulation of catalytic activity |
|
GO:0043209 |
myelin sheath |
|
GO:0043375 |
CD8-positive, alpha-beta T cell lineage commitment |
|
GO:0043496 |
regulation of protein homodimerization activity |
|
GO:0043497 |
regulation of protein heterodimerization activity |
|
GO:0043524 |
negative regulation of neuron apoptosis |
|
GO:0043565 |
sequence-specific DNA binding |
|
GO:0043583 |
ear development |
|
GO:0043627 |
response to estrogen stimulus |
|
GO:0045069 |
regulation of viral genome replication |
|
GO:0045471 |
response to ethanol |
|
GO:0045636 |
positive regulation of melanocyte differentiation |
|
GO:0045930 |
negative regulation of mitotic cell cycle |
|
GO:0046671 |
negative regulation of retinal cell programmed cell death |
|
GO:0046688 |
response to copper ion |
|
GO:0046902 |
regulation of mitochondrial membrane permeability |
|
GO:0046930 |
pore complex |
|
GO:0046982 |
protein heterodimerization activity |
|
GO:0048041 |
focal adhesion assembly |
|
GO:0048087 |
positive regulation of developmental pigmentation |
|
GO:0048536 |
spleen development |
|
GO:0048538 |
thymus development |
|
GO:0048546 |
digestive tract morphogenesis |
|
GO:0048589 |
developmental growth |
|
GO:0048599 |
oocyte development |
|
GO:0048743 |
positive regulation of skeletal muscle fiber development |
|
GO:0048753 |
pigment granule organization |
|
GO:0048873 |
homeostasis of number of cells within a tissue |
|
GO:0050853 |
B cell receptor signaling pathway |
|
GO:0051402 |
neuron apoptosis |
|
GO:0051412 |
response to corticosterone stimulus |
|
GO:0051434 |
BH3 domain binding |
|
GO:0051593 |
response to folic acid |
|
GO:0051607 |
defense response to virus |
|
GO:0051721 |
protein phosphatase 2A binding |
|
GO:0051726 |
regulation of cell cycle |
|
GO:0051789 |
response to protein stimulus |
|
GO:0051881 |
regulation of mitochondrial membrane potential |
|
GO:0051902 |
negative regulation of mitochondrial depolarization |
|
GO:0051924 |
regulation of calcium ion transport |
|
GO:0070059 |
apoptosis in response to endoplasmic reticulum stress |
