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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG000503

Entrez Gene ID

718

Official Gene Symbol

C3

Synonyms

AHUS5|ARMD9|ASP|CPAMD1

Gene name

complement component 3

Gene Type

protein-coding

Chromosome

19

Genomics Location

19p13.3-p13.2

Known cancer genes

Yes

Protein products

Complement C3

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Primary biliary cirrhosis

Nonalcoholic steatohepatitis

Primary sclerosing cholangitis

Database cross reference

HGNC:1318
MIM:120700
Ensembl:ENSG00000125730
HPRD:00400
RefSeq Genomic nucleotide accession:AC_000062
RefSeq Genomic nucleotide gi:89161197

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001798

positive regulation of type IIa hypersensitivity

GO:0001970

positive regulation of activation of membrane attack complex

GO:0004866

endopeptidase inhibitor activity

GO:0005102

receptor binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0006954

inflammatory response

GO:0006955

immune response

GO:0006956

complement activation

GO:0006957

complement activation, alternative pathway

GO:0006958

complement activation, classical pathway

GO:0007165

signal transduction

GO:0007186

G-protein coupled receptor protein signaling pathway

GO:0010575

positive regulation vascular endothelial growth factor production

GO:0045087

innate immune response

GO:0045766

positive regulation of angiogenesis

GO:0050766

positive regulation of phagocytosis

GO:0050776

regulation of immune response