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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG000571

Entrez Gene ID

811

Official Gene Symbol

CALR

Synonyms

CRT|FLJ26680|RO|SSA|cC1qR

Gene name

calreticulin

Gene Type

protein-coding

Chromosome

19

Genomics Location

19p13.3-p13.2

Known cancer genes

Yes

Protein products

Calreticulin

Related liver disease name

Liver fibrosis and liver cirrhosis

Hepatitis C

Chronic hepatitis C

Hepatocellular carcinoma

Primary biliary cirrhosis

Schistosomiasis

Database cross reference

HGNC:1455
MIM:109091
Ensembl:ENSG00000179218
HPRD:00169
RefSeq Genomic nucleotide accession:AC_000062
RefSeq Genomic nucleotide gi:89161197

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0001669

acrosomal vesicle

GO:0001849

complement component C1q binding

GO:0002502

peptide antigen assembly with MHC class I protein complex

GO:0003677

DNA binding

GO:0003729

mRNA binding

GO:0005178

integrin binding

GO:0005506

iron ion binding

GO:0005509

calcium ion binding

GO:0005515

protein binding

GO:0005529

sugar binding

GO:0005576

extracellular region

GO:0005578

proteinaceous extracellular matrix

GO:0005615

extracellular space

GO:0005622

intracellular

GO:0005625

soluble fraction

GO:0005634

nucleus

GO:0005737

cytoplasm

GO:0005783

endoplasmic reticulum

GO:0005788

endoplasmic reticulum lumen

GO:0005792

microsome

GO:0005794

Golgi apparatus

GO:0005829

cytosol

GO:0005844

polysome

GO:0006355

regulation of transcription, DNA-dependent

GO:0006457

protein folding

GO:0006611

protein export from nucleus

GO:0006874

cellular calcium ion homeostasis

GO:0007050

cell cycle arrest

GO:0007283

spermatogenesis

GO:0008270

zinc ion binding

GO:0008284

positive regulation of cell proliferation

GO:0009897

external side of plasma membrane

GO:0009986

cell surface

GO:0016529

sarcoplasmic reticulum

GO:0017148

negative regulation of translation

GO:0018279

protein N-linked glycosylation via asparagine

GO:0022417

protein maturation by protein folding

GO:0030246

carbohydrate binding

GO:0030866

cortical actin cytoskeleton organization

GO:0031625

ubiquitin protein ligase binding

GO:0032355

response to estradiol stimulus

GO:0033144

negative regulation of steroid hormone receptor signaling pathway

GO:0033574

response to testosterone stimulus

GO:0040020

regulation of meiosis

GO:0042277

peptide binding

GO:0042493

response to drug

GO:0042562

hormone binding

GO:0042824

MHC class I peptide loading complex

GO:0042921

glucocorticoid receptor signaling pathway

GO:0042981

regulation of apoptosis

GO:0043687

post-translational protein modification

GO:0044183

protein binding involved in protein folding

GO:0044267

cellular protein metabolic process

GO:0045665

negative regulation of neuron differentiation

GO:0045740

positive regulation of DNA replication

GO:0045787

positive regulation of cell cycle

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

GO:0048471

perinuclear region of cytoplasm

GO:0050681

androgen receptor binding

GO:0050766

positive regulation of phagocytosis

GO:0050821

protein stabilization

GO:0051082

unfolded protein binding

GO:0051087

chaperone binding

GO:0051208

sequestering of calcium ion

GO:0055007

cardiac muscle cell differentiation

GO:0071285

cellular response to lithium ion

GO:0071310

cellular response to organic substance

GO:0090398

cellular senescence