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LiverAtlas Gene ID	HuLG000600
Entrez Gene ID	841
Official Gene Symbol	CASP8
Synonyms	ALPS2B\|CAP4\|CaspN8\|FLICE\|FLJ17672\|MACH\|MCH5\|MGC78473
Gene name	caspase 8, apoptosis-related cysteine peptidase
Gene Type	protein-coding
Chromosome	2
Genomics Location	2q33-q34
Known cancer genes	Yes
Protein products	Caspase-8
Related liver disease name	Hepatitis Viral hepatitis Hepatitis A Hepatitis B Hepatitis C Chronic hepatitis C Hepatitis D Hepatitis E Chronic hepatitis Hepatocellular carcinoma Primary biliary cirrhosis Intrahepatic cholangiocarcinoma Hepatocellular carcinoma
Database cross reference	HGNC:1509 MIM:601763 Ensembl:ENSG00000064012 HPRD:03459 RefSeq Genomic nucleotide accession:AC_000045 RefSeq Genomic nucleotide gi:89161198

GO ID	GO annotation
GO:0001525	angiogenesis
GO:0001841	neural tube formation
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0006508	proteolysis
GO:0006915	apoptosis
GO:0006919	activation of caspase activity
GO:0006921	cellular component disassembly involved in apoptosis
GO:0007507	heart development
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0008624	induction of apoptosis by extracellular signals
GO:0008629	induction of apoptosis by intracellular signals
GO:0008633	activation of pro-apoptotic gene products
GO:0009409	response to cold
GO:0030225	macrophage differentiation
GO:0030690	Noc1p-Noc2p complex
GO:0031264	death-inducing signaling complex
GO:0031265	CD95 death-inducing signaling complex
GO:0032025	response to cobalt ion
GO:0032355	response to estradiol stimulus
GO:0032496	response to lipopolysaccharide
GO:0034612	response to tumor necrosis factor
GO:0042981	regulation of apoptosis
GO:0043005	neuron projection
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0044297	cell body
GO:0045121	membrane raft
GO:0045471	response to ethanol
GO:0046677	response to antibiotic
GO:0051291	protein heterooligomerization
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0071260	cellular response to mechanical stimulus