HuLG000618

Entrez Gene ID

868

Official Gene Symbol

CBLB

Synonyms

DKFZp686J10223|DKFZp779A0729|DKFZp779F1443|FLJ36865|FLJ41152|RNF56

Gene name

Cas-Br-M (murine) ecotropic retroviral transforming sequence b

Gene Type

protein-coding

Chromosome

3

Genomics Location

3q13.11

Known cancer genes

Yes

Protein products

CBL-B

cDNA FLJ36865 fis, clone ASTRO2016148, highly similar to E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-)

E3 ubiquitin-protein ligase CBL-B

Uncharacterized protein

Related liver disease name

Hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Database cross reference

HGNC:1542
MIM:604491
Ensembl:ENSG00000114423
HPRD:05136
RefSeq Genomic nucleotide accession:AC_000046
RefSeq Genomic nucleotide gi:89161204

GO annotation

GO:0002669

positive regulation of T cell anergy

GO:0004871

signal transducer activity

GO:0005509

calcium ion binding

GO:0005634

nucleus

GO:0005730

nucleolus

GO:0005737

cytoplasm

GO:0006607

NLS-bearing substrate import into nucleus

GO:0006955

immune response

GO:0007165

signal transduction

GO:0007166

cell surface receptor linked signaling pathway

GO:0008270

zinc ion binding

GO:0016874

ligase activity

GO:0035556

intracellular signal transduction

GO:0042110

T cell activation

GO:0045732

positive regulation of protein catabolic process

GO:0046642

negative regulation of alpha-beta T cell proliferation

GO:0050860

negative regulation of T cell receptor signaling pathway