Gene basic information
| LiverAtlas Gene ID |
HuLG000741 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
CDKN1A |
|
Synonyms |
CAP20|CDKN1|CIP1|MDAN6|P21|SDI1|WAF1|p21CIP1 |
|
Gene name |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
|
Gene Type |
protein-coding |
|
Chromosome |
6 |
|
Genomics Location |
6p21.2 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:1784
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000075 |
cell cycle checkpoint |
|
GO:0000079 |
regulation of cyclin-dependent protein kinase activity |
|
GO:0000080 |
G1 phase of mitotic cell cycle |
|
GO:0000082 |
G1/S transition of mitotic cell cycle |
|
GO:0000084 |
S phase of mitotic cell cycle |
|
GO:0000086 |
G2/M transition of mitotic cell cycle |
|
GO:0000278 |
mitotic cell cycle |
|
GO:0000307 |
cyclin-dependent protein kinase holoenzyme complex |
|
GO:0004860 |
protein kinase inhibitor activity |
|
GO:0004861 |
cyclin-dependent protein kinase inhibitor activity |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0006974 |
response to DNA damage stimulus |
|
GO:0006977 |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
|
GO:0007050 |
cell cycle arrest |
|
GO:0007265 |
Ras protein signal transduction |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0008629 |
induction of apoptosis by intracellular signals |
|
GO:0009411 |
response to UV |
|
GO:0009636 |
response to toxin |
|
GO:0010243 |
response to organic nitrogen |
|
GO:0014070 |
response to organic cyclic compound |
|
GO:0019912 |
cyclin-dependent protein kinase activating kinase activity |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0030332 |
cyclin binding |
|
GO:0030890 |
positive regulation of B cell proliferation |
|
GO:0031100 |
organ regeneration |
|
GO:0031668 |
cellular response to extracellular stimulus |
|
GO:0032403 |
protein complex binding |
|
GO:0042326 |
negative regulation of phosphorylation |
|
GO:0042493 |
response to drug |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043068 |
positive regulation of programmed cell death |
|
GO:0045736 |
negative regulation of cyclin-dependent protein kinase activity |
|
GO:0045768 |
positive regulation of anti-apoptosis |
|
GO:0046685 |
response to arsenic-containing substance |
|
GO:0046872 |
metal ion binding |
|
GO:0048146 |
positive regulation of fibroblast proliferation |
|
GO:0051412 |
response to corticosterone stimulus |
|
GO:0055093 |
response to hyperoxia |
|
GO:0070557 |
PCNA-p21 complex |
|
GO:0071479 |
cellular response to ionizing radiation |
|
GO:0090398 |
cellular senescence |
|
GO:0090400 |
stress-induced premature senescence |
|
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
