Gene basic information
| LiverAtlas Gene ID |
HuLG000742 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
CDKN1B |
|
Synonyms |
CDKN4|KIP1|MEN1B|MEN4|P27KIP1 |
|
Gene name |
cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
|
Gene Type |
protein-coding |
|
Chromosome |
12 |
|
Genomics Location |
12p13.1-p12 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:1785
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000075 |
cell cycle checkpoint |
|
GO:0000079 |
regulation of cyclin-dependent protein kinase activity |
|
GO:0000080 |
G1 phase of mitotic cell cycle |
|
GO:0000082 |
G1/S transition of mitotic cell cycle |
|
GO:0000084 |
S phase of mitotic cell cycle |
|
GO:0000278 |
mitotic cell cycle |
|
GO:0004860 |
protein kinase inhibitor activity |
|
GO:0004861 |
cyclin-dependent protein kinase inhibitor activity |
|
GO:0005072 |
transforming growth factor beta receptor, cytoplasmic mediator activity |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005737 |
cytoplasm |
|
GO:0005768 |
endosome |
|
GO:0005829 |
cytosol |
|
GO:0006813 |
potassium ion transport |
|
GO:0006917 |
induction of apoptosis |
|
GO:0006977 |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
|
GO:0007050 |
cell cycle arrest |
|
GO:0007605 |
sensory perception of sound |
|
GO:0008284 |
positive regulation of cell proliferation |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0019903 |
protein phosphatase binding |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0031116 |
positive regulation of microtubule polymerization |
|
GO:0033673 |
negative regulation of kinase activity |
|
GO:0042326 |
negative regulation of phosphorylation |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0045732 |
positive regulation of protein catabolic process |
|
GO:0045736 |
negative regulation of cyclin-dependent protein kinase activity |
|
GO:0045892 |
negative regulation of transcription, DNA-dependent |
|
GO:0048011 |
nerve growth factor receptor signaling pathway |
|
GO:0048015 |
phosphatidylinositol-mediated signaling |
|
GO:0048102 |
autophagic cell death |
|
GO:0048839 |
inner ear development |
|
GO:0051271 |
negative regulation of cellular component movement |
|
GO:0060770 |
negative regulation of epithelial cell proliferation involved in prostate gland development |
|
GO:0071236 |
cellular response to antibiotic |
|
GO:0071285 |
cellular response to lithium ion |
|
GO:0071407 |
cellular response to organic cyclic compound |
