Gene basic information
| LiverAtlas Gene ID |
HuLG000744 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
CDKN2A |
|
Synonyms |
ARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTSN1|MTS1|P14|P14ARF|P16|P16NINK4A|P16INK4|P16INK4A|P19|P19ARF|TP16 |
|
Gene name |
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) |
|
Gene Type |
protein-coding |
|
Chromosome |
9 |
|
Genomics Location |
9p21 |
|
Known cancer genes |
Yes |
|
Protein products |
Cyclin-dependent kinase inhibitor Cyclin-dependent kinase inhibitor 2A Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 Cyclin-dependent kinase inhibitor 2A, isoform 4 |
|
Related liver disease name |
Liver fibrosis and liver cirrhosis |
|
Database cross reference |
HGNC:1787
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000075 |
cell cycle checkpoint |
|
GO:0000080 |
G1 phase of mitotic cell cycle |
|
GO:0000082 |
G1/S transition of mitotic cell cycle |
|
GO:0000209 |
protein polyubiquitination |
|
GO:0000278 |
mitotic cell cycle |
|
GO:0001652 |
granular component |
|
GO:0001953 |
negative regulation of cell-matrix adhesion |
|
GO:0002039 |
p53 binding |
|
GO:0003677 |
DNA binding |
|
GO:0004861 |
cyclin-dependent protein kinase inhibitor activity |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005730 |
nucleolus |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0006309 |
DNA fragmentation involved in apoptotic nuclear change |
|
GO:0006364 |
rRNA processing |
|
GO:0006469 |
negative regulation of protein kinase activity |
|
GO:0006917 |
induction of apoptosis |
|
GO:0006919 |
activation of caspase activity |
|
GO:0007050 |
cell cycle arrest |
|
GO:0007265 |
Ras protein signal transduction |
|
GO:0008134 |
transcription factor binding |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0008544 |
epidermis development |
|
GO:0008637 |
apoptotic mitochondrial changes |
|
GO:0009303 |
rRNA transcription |
|
GO:0010389 |
regulation of G2/M transition of mitotic cell cycle |
|
GO:0016604 |
nuclear body |
|
GO:0019901 |
protein kinase binding |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0030889 |
negative regulation of B cell proliferation |
|
GO:0031647 |
regulation of protein stability |
|
GO:0031648 |
protein destabilization |
|
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
|
GO:0033088 |
negative regulation of immature T cell proliferation in thymus |
|
GO:0033235 |
positive regulation of protein sumoylation |
|
GO:0033600 |
negative regulation of mammary gland epithelial cell proliferation |
|
GO:0034393 |
positive regulation of smooth muscle cell apoptosis |
|
GO:0042326 |
negative regulation of phosphorylation |
|
GO:0043234 |
protein complex |
|
GO:0043517 |
positive regulation of DNA damage response, signal transduction by p53 class mediator |
|
GO:0045736 |
negative regulation of cyclin-dependent protein kinase activity |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046822 |
regulation of nucleocytoplasmic transport |
|
GO:0046825 |
regulation of protein export from nucleus |
|
GO:0048103 |
somatic stem cell division |
|
GO:0050821 |
protein stabilization |
|
GO:0051059 |
NF-kappaB binding |
|
GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
|
GO:0051444 |
negative regulation of ubiquitin-protein ligase activity |
|
GO:0055105 |
ubiquitin-protein ligase inhibitor activity |
|
GO:0060058 |
positive regulation of apoptosis involved in mammary gland involution |
|
GO:0070215 |
MDM2 binding |
|
GO:0070534 |
protein K63-linked ubiquitination |
|
GO:0071158 |
positive regulation of cell cycle arrest |
|
GO:0090398 |
cellular senescence |
|
GO:0090399 |
replicative senescence |
|
GO:2000111 |
positive regulation of macrophage apoptosis |
