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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG000828

Entrez Gene ID

1147

Official Gene Symbol

CHUK

Synonyms

IKBKA|IKKNalpha|IKK1|IKKA|NFKBIKA|TCF16

Gene name

conserved helix-loop-helix ubiquitous kinase

Gene Type

protein-coding

Chromosome

10

Genomics Location

10q24-q25

Known cancer genes

Yes

Protein products

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Conserved helix-loop-helix ubiquitous kinase

Related liver disease name

Hepatitis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Database cross reference

HGNC:1974
MIM:600664
Ensembl:ENSG00000213341
HPRD:02811
RefSeq Genomic nucleotide accession:AC_000053
RefSeq Genomic nucleotide gi:89161186

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000166

nucleotide binding

GO:0002011

morphogenesis of an epithelial sheet

GO:0002224

toll-like receptor signaling pathway

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

GO:0002756

MyD88-independent toll-like receptor signaling pathway

GO:0004672

protein kinase activity

GO:0005515

protein binding

GO:0005524

ATP binding

GO:0005634

nucleus

GO:0005730

nucleolus

GO:0005737

cytoplasm

GO:0005829

cytosol

GO:0006468

protein phosphorylation

GO:0006955

immune response

GO:0007252

I-kappaB phosphorylation

GO:0007595

lactation

GO:0008063

Toll signaling pathway

GO:0008384

IkappaB kinase activity

GO:0009653

anatomical structure morphogenesis

GO:0009898

internal side of plasma membrane

GO:0030316

osteoclast differentiation

GO:0033598

mammary gland epithelial cell proliferation

GO:0034130

toll-like receptor 1 signaling pathway

GO:0034134

toll-like receptor 2 signaling pathway

GO:0034138

toll-like receptor 3 signaling pathway

GO:0034142

toll-like receptor 4 signaling pathway

GO:0035631

CD40 receptor complex

GO:0042475

odontogenesis of dentine-containing tooth

GO:0042802

identical protein binding

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

GO:0043231

intracellular membrane-bounded organelle

GO:0045087

innate immune response

GO:0048011

nerve growth factor receptor signaling pathway

GO:0048015

phosphatidylinositol-mediated signaling

GO:0050852

T cell receptor signaling pathway

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO:0060749

mammary gland alveolus development