Gene basic information
LiverAtlas Gene ID |
HuLG000928 |
Entrez Gene ID |
|
Official Gene Symbol |
COMT |
Gene name |
catechol-O-methyltransferase |
Gene Type |
protein-coding |
Chromosome |
22 |
Genomics Location |
22q11.21-q11.23|22q11.21 |
Known cancer genes |
Yes |
Protein products |
Soluble catechol-O-methyltransferase |
Related liver disease name |
|
Database cross reference |
HGNC:2228
|
Liver relevance
HCC significant genes |
Yes/No |
Yes |
Evidence |
EHCO HCC.net OncoDB |
|
Quality score |
|
Ontology annotation
GO ID |
GO annotation |
GO:0000287 |
magnesium ion binding |
GO:0005515 |
protein binding |
GO:0005624 |
membrane fraction |
GO:0005625 |
soluble fraction |
GO:0005737 |
cytoplasm |
GO:0005792 |
microsome |
GO:0005829 |
cytosol |
GO:0005886 |
plasma membrane |
GO:0006584 |
catecholamine metabolic process |
GO:0006805 |
xenobiotic metabolic process |
GO:0007268 |
synaptic transmission |
GO:0007565 |
female pregnancy |
GO:0007612 |
learning |
GO:0008168 |
methyltransferase activity |
GO:0008171 |
O-methyltransferase activity |
GO:0008210 |
estrogen metabolic process |
GO:0014070 |
response to organic cyclic compound |
GO:0016021 |
integral to membrane |
GO:0016206 |
catechol O-methyltransferase activity |
GO:0016740 |
transferase activity |
GO:0032259 |
methylation |
GO:0032496 |
response to lipopolysaccharide |
GO:0042135 |
neurotransmitter catabolic process |
GO:0042136 |
neurotransmitter biosynthetic process |
GO:0042420 |
dopamine catabolic process |
GO:0042493 |
response to drug |
GO:0043231 |
intracellular membrane-bounded organelle |
GO:0045963 |
negative regulation of dopamine metabolic process |
GO:0048265 |
response to pain |
GO:0048609 |
multicellular organismal reproductive process |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
GO:0050668 |
positive regulation of homocysteine metabolic process |