Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG000928

Entrez Gene ID

1312

Official Gene Symbol

COMT

Gene name

catechol-O-methyltransferase

Gene Type

protein-coding

Chromosome

22

Genomics Location

22q11.21-q11.23|22q11.21

Known cancer genes

Yes

Protein products

Soluble catechol-O-methyltransferase

Membrane bound catechol-O-methyltransferase

Catechol O-methyltransferase

COMT protein

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Database cross reference

HGNC:2228
MIM:116790
Ensembl:ENSG00000093010
HPRD:00284
RefSeq Genomic nucleotide accession:AC_000065
RefSeq Genomic nucleotide gi:89161202

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net OncoDB

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000287

magnesium ion binding

GO:0005515

protein binding

GO:0005624

membrane fraction

GO:0005625

soluble fraction

GO:0005737

cytoplasm

GO:0005792

microsome

GO:0005829

cytosol

GO:0005886

plasma membrane

GO:0006584

catecholamine metabolic process

GO:0006805

xenobiotic metabolic process

GO:0007268

synaptic transmission

GO:0007565

female pregnancy

GO:0007612

learning

GO:0008168

methyltransferase activity

GO:0008171

O-methyltransferase activity

GO:0008210

estrogen metabolic process

GO:0014070

response to organic cyclic compound

GO:0016021

integral to membrane

GO:0016206

catechol O-methyltransferase activity

GO:0016740

transferase activity

GO:0032259

methylation

GO:0032496

response to lipopolysaccharide

GO:0042135

neurotransmitter catabolic process

GO:0042136

neurotransmitter biosynthetic process

GO:0042420

dopamine catabolic process

GO:0042493

response to drug

GO:0043231

intracellular membrane-bounded organelle

GO:0045963

negative regulation of dopamine metabolic process

GO:0048265

response to pain

GO:0048609

multicellular organismal reproductive process

GO:0048662

negative regulation of smooth muscle cell proliferation

GO:0050668

positive regulation of homocysteine metabolic process