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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG001056

Entrez Gene ID

1490

Official Gene Symbol

CTGF

Synonyms

CCN2|HCS24|IGFBP8|MGC102839|NOV2

Gene name

connective tissue growth factor

Gene Type

protein-coding

Chromosome

6

Genomics Location

6q23.1

Known cancer genes

Yes

Protein products

Connective tissue growth factor

Connective tissue growth factor

CTGF protein

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Nonalcoholic steatohepatitis

Database cross reference

HGNC:2500
MIM:121009
Ensembl:ENSG00000118523
HPRD:00412
RefSeq Genomic nucleotide accession:AC_000049
RefSeq Genomic nucleotide gi:89161209

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net OncoDB

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001502

cartilage condensation

GO:0001503

ossification

GO:0001525

angiogenesis

GO:0001558

regulation of cell growth

GO:0001934

positive regulation of protein phosphorylation

GO:0001968

fibronectin binding

GO:0005178

integrin binding

GO:0005520

insulin-like growth factor binding

GO:0005576

extracellular region

GO:0005578

proteinaceous extracellular matrix

GO:0005615

extracellular space

GO:0005801

cis-Golgi network

GO:0005829

cytosol

GO:0005886

plasma membrane

GO:0005938

cell cortex

GO:0006260

DNA replication

GO:0007155

cell adhesion

GO:0007160

cell-matrix adhesion

GO:0007229

integrin-mediated signaling pathway

GO:0008083

growth factor activity

GO:0008201

heparin binding

GO:0008284

positive regulation of cell proliferation

GO:0008543

fibroblast growth factor receptor signaling pathway

GO:0008544

epidermis development

GO:0009611

response to wounding

GO:0009749

response to glucose stimulus

GO:0010260

organ senescence

GO:0010628

positive regulation of gene expression

GO:0010942

positive regulation of cell death

GO:0014070

response to organic cyclic compound

GO:0016477

cell migration

GO:0030154

cell differentiation

GO:0030324

lung development

GO:0032355

response to estradiol stimulus

GO:0032967

positive regulation of collagen biosynthetic process

GO:0034059

response to anoxia

GO:0043200

response to amino acid stimulus

GO:0043280

positive regulation of caspase activity

GO:0043434

response to peptide hormone stimulus

GO:0044255

cellular lipid metabolic process

GO:0048471

perinuclear region of cytoplasm

GO:0050867

positive regulation of cell activation

GO:0051385

response to mineralocorticoid stimulus

GO:0060401

cytosolic calcium ion transport

GO:0060452

positive regulation of cardiac muscle contraction

GO:0070278

extracellular matrix constituent secretion

GO:0070318

positive regulation of G0 to G1 transition

GO:0070542

response to fatty acid