HuLG001114

Entrez Gene ID

1576

Official Gene Symbol

CYP3A4

Synonyms

CP33|CP34|CYP3A|CYP3A3|CYPIIIA3|CYPIIIA4|HLP|MGC126680|NFN25|P450C3|P450PCN1

Gene name

cytochrome P450, family 3, subfamily A, polypeptide 4

Gene Type

protein-coding

Chromosome

7

Genomics Location

7q21.1

Known cancer genes

Yes

Protein products

Cytochrome P450 3A4

Cytochrome P450 family 3 subfamily A polypeptide 4

Cytochrome P450

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Drug-induced hepatitis

Hepatocellular carcinoma

Primary biliary cirrhosis

Hepatocellular carcinoma

Database cross reference

HGNC:2637
MIM:124010
Ensembl:ENSG00000160868
HPRD:00484
RefSeq Genomic nucleotide accession:AC_000050
RefSeq Genomic nucleotide gi:89161211

Yes/No

Yes

Evidence

Translational level from literatures

Quality score

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

GO annotation

GO:0004497

monooxygenase activity

GO:0005496

steroid binding

GO:0005506

iron ion binding

GO:0005737

cytoplasm

GO:0005783

endoplasmic reticulum

GO:0005789

endoplasmic reticulum membrane

GO:0005792

microsome

GO:0006629

lipid metabolic process

GO:0006706

steroid catabolic process

GO:0006805

xenobiotic metabolic process

GO:0008202

steroid metabolic process

GO:0008209

androgen metabolic process

GO:0008395

steroid hydroxylase activity

GO:0009055

electron carrier activity

GO:0009822

alkaloid catabolic process

GO:0009986

cell surface

GO:0016020

membrane

GO:0016021

integral to membrane

GO:0016098

monoterpenoid metabolic process

GO:0016491

oxidoreductase activity

GO:0016712

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

GO:0017144

drug metabolic process

GO:0019825

oxygen binding

GO:0019899

enzyme binding

GO:0020037

heme binding

GO:0030343

vitamin D3 25-hydroxylase activity

GO:0033780

taurochenodeoxycholate 6alpha-hydroxylase activity

GO:0034875

caffeine oxidase activity

GO:0042359

vitamin D metabolic process

GO:0042737

drug catabolic process

GO:0042738

exogenous drug catabolic process

GO:0046483

heterocycle metabolic process

GO:0046872

metal ion binding

GO:0047638

albendazole monooxygenase activity

GO:0050591

quinine 3-monooxygenase activity

GO:0050649

testosterone 6-beta-hydroxylase activity

GO:0055114

oxidation-reduction process

GO:0070576

vitamin D 24-hydroxylase activity

GO:0070989

oxidative demethylation