HuLG001131

Entrez Gene ID

1594

Official Gene Symbol

CYP27B1

Synonyms

CP2B|CYP1|CYP1alpha|CYP27B|P450c1|PDDR|VDD1|VDDR|VDDRI|VDR

Gene name

cytochrome P450, family 27, subfamily B, polypeptide 1

Gene Type

protein-coding

Chromosome

12

Genomics Location

12q13.1-q13.3

Known cancer genes

Yes

Protein products

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

25-hydroxyvitamin D-1-alpha-hydroxylase

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Autoimmune hepatitis

Alcoholic liver cirrhosis

Biliary cirrhosis

Primary biliary cirrhosis

Database cross reference

HGNC:2606
MIM:609506
Ensembl:ENSG00000111012
HPRD:02031
RefSeq Genomic nucleotide accession:AC_000055
RefSeq Genomic nucleotide gi:89161189

GO annotation

GO:0004497

monooxygenase activity

GO:0004498

calcidiol 1-monooxygenase activity

GO:0005737

cytoplasm

GO:0005739

mitochondrion

GO:0005741

mitochondrial outer membrane

GO:0006766

vitamin metabolic process

GO:0006805

xenobiotic metabolic process

GO:0006816

calcium ion transport

GO:0008202

steroid metabolic process

GO:0008285

negative regulation of cell proliferation

GO:0009055

electron carrier activity

GO:0010956

negative regulation of calcidiol 1-monooxygenase activity

GO:0010980

positive regulation of vitamin D 24-hydroxylase activity

GO:0016020

membrane

GO:0016705

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

GO:0020037

heme binding

GO:0030282

bone mineralization

GO:0030308

negative regulation of cell growth

GO:0030500

regulation of bone mineralization

GO:0032496

response to lipopolysaccharide

GO:0033280

response to vitamin D

GO:0034341

response to interferon-gamma

GO:0034612

response to tumor necrosis factor

GO:0042359

vitamin D metabolic process

GO:0042368

vitamin D biosynthetic process

GO:0042369

vitamin D catabolic process

GO:0042446

hormone biosynthetic process

GO:0043627

response to estrogen stimulus

GO:0045618

positive regulation of keratinocyte differentiation

GO:0046697

decidualization

GO:0046872

metal ion binding

GO:0055074

calcium ion homeostasis

GO:0070314

G1 to G0 transition

GO:0070564

positive regulation of vitamin D receptor signaling pathway