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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG001252

Entrez Gene ID

1788

Official Gene Symbol

DNMT3A

Synonyms

DNMT3A2|M.HsaIIIA

Gene name

DNA (cytosine-5-)-methyltransferase 3 alpha

Gene Type

protein-coding

Chromosome

2

Genomics Location

2p23

Known cancer genes

Yes

Protein products

DNA (cytosine-5)-methyltransferase 3A

Uncharacterized protein

DNMT3A protein

DNMT3A protein

Related liver disease name

Liver fibrosis and liver cirrhosis

Chronic hepatitis

Hepatocellular carcinoma

Database cross reference

HGNC:2978
MIM:602769
Ensembl:ENSG00000119772
HPRD:04141
RefSeq Genomic nucleotide accession:AC_000045
RefSeq Genomic nucleotide gi:89161198

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net OncoDB

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0000775

chromosome, centromeric region

GO:0000791

euchromatin

GO:0003677

DNA binding

GO:0003682

chromatin binding

GO:0003886

DNA (cytosine-5-)-methyltransferase activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005720

nuclear heterochromatin

GO:0005737

cytoplasm

GO:0006306

DNA methylation

GO:0006346

methylation-dependent chromatin silencing

GO:0006349

regulation of gene expression by genetic imprinting

GO:0007283

spermatogenesis

GO:0008168

methyltransferase activity

GO:0016363

nuclear matrix

GO:0016568

chromatin modification

GO:0016740

transferase activity

GO:0043045

DNA methylation involved in embryo development

GO:0043046

DNA methylation involved in gamete generation

GO:0046872

metal ion binding

GO:0090116

C-5 methylation of cytosine