HuLG001267

Entrez Gene ID

1806

Official Gene Symbol

DPYD

Synonyms

DHP|DHPDHASE|DPD|MGC132008|MGC70799

Gene name

dihydropyrimidine dehydrogenase

Gene Type

protein-coding

Chromosome

1

Genomics Location

1p22

Known cancer genes

Yes

Protein products

Dihydropyrimidine dehydrogenase [NADP+]

DPYD protein

Related liver disease name

Hepatocellular carcinoma

Intrahepatic cholangiocarcinoma

Database cross reference

HGNC:3012
MIM:612779
Ensembl:ENSG00000188641
HPRD:02036
RefSeq Genomic nucleotide accession:AC_000044
RefSeq Genomic nucleotide gi:89161184

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

GO annotation

GO:0004158

dihydroorotate oxidase activity

GO:0005737

cytoplasm

GO:0005829

cytosol

GO:0006145

purine base catabolic process

GO:0006206

pyrimidine base metabolic process

GO:0006207

de novo' pyrimidine base biosynthetic process

GO:0006208

pyrimidine base catabolic process

GO:0006210

thymine catabolic process

GO:0006212

uracil catabolic process

GO:0006214

thymidine catabolic process

GO:0006222

UMP biosynthetic process

GO:0009055

electron carrier activity

GO:0016491

oxidoreductase activity

GO:0017113

dihydropyrimidine dehydrogenase (NADP+) activity

GO:0042803

protein homodimerization activity

GO:0046135

pyrimidine nucleoside catabolic process

GO:0046872

metal ion binding

GO:0050660

flavin adenine dinucleotide binding

GO:0050661

NADP binding

GO:0051539

4 iron, 4 sulfur cluster binding

GO:0055086

nucleobase, nucleoside and nucleotide metabolic process