Gene basic information
| LiverAtlas Gene ID |
HuLG001333 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
EDN1 |
|
Synonyms |
ET1|HDLCQ7|PPET1 |
|
Gene name |
endothelin 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
6 |
|
Genomics Location |
6p24.1 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:3176
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
|
GO:0001516 |
prostaglandin biosynthetic process |
|
GO:0001569 |
patterning of blood vessels |
|
GO:0001666 |
response to hypoxia |
|
GO:0001701 |
in utero embryonic development |
|
GO:0003100 |
regulation of systemic arterial blood pressure by endothelin |
|
GO:0005125 |
cytokine activity |
|
GO:0005179 |
hormone activity |
|
GO:0005576 |
extracellular region |
|
GO:0005615 |
extracellular space |
|
GO:0005737 |
cytoplasm |
|
GO:0006885 |
regulation of pH |
|
GO:0007166 |
cell surface receptor linked signaling pathway |
|
GO:0007186 |
G-protein coupled receptor protein signaling pathway |
|
GO:0007204 |
elevation of cytosolic calcium ion concentration |
|
GO:0007205 |
activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway |
|
GO:0007243 |
intracellular protein kinase cascade |
|
GO:0007267 |
cell-cell signaling |
|
GO:0007507 |
heart development |
|
GO:0007585 |
respiratory gaseous exchange |
|
GO:0007589 |
body fluid secretion |
|
GO:0008217 |
regulation of blood pressure |
|
GO:0008284 |
positive regulation of cell proliferation |
|
GO:0009953 |
dorsal/ventral pattern formation |
|
GO:0010259 |
multicellular organismal aging |
|
GO:0010460 |
positive regulation of heart rate |
|
GO:0010595 |
positive regulation of endothelial cell migration |
|
GO:0010613 |
positive regulation of cardiac muscle hypertrophy |
|
GO:0014032 |
neural crest cell development |
|
GO:0014065 |
phosphatidylinositol 3-kinase cascade |
|
GO:0014824 |
artery smooth muscle contraction |
|
GO:0014826 |
vein smooth muscle contraction |
|
GO:0015758 |
glucose transport |
|
GO:0019229 |
regulation of vasoconstriction |
|
GO:0019722 |
calcium-mediated signaling |
|
GO:0030072 |
peptide hormone secretion |
|
GO:0030185 |
nitric oxide transport |
|
GO:0030195 |
negative regulation of blood coagulation |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0030593 |
neutrophil chemotaxis |
|
GO:0030818 |
negative regulation of cAMP biosynthetic process |
|
GO:0031583 |
activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway |
|
GO:0031707 |
endothelin A receptor binding |
|
GO:0031708 |
endothelin B receptor binding |
|
GO:0032269 |
negative regulation of cellular protein metabolic process |
|
GO:0032496 |
response to lipopolysaccharide |
|
GO:0033574 |
response to testosterone stimulus |
|
GO:0035094 |
response to nicotine |
|
GO:0042310 |
vasoconstriction |
|
GO:0042313 |
protein kinase C deactivation |
|
GO:0042474 |
middle ear morphogenesis |
|
GO:0042493 |
response to drug |
|
GO:0043179 |
rhythmic excitation |
|
GO:0043200 |
response to amino acid stimulus |
|
GO:0043406 |
positive regulation of MAP kinase activity |
|
GO:0043507 |
positive regulation of JUN kinase activity |
|
GO:0045321 |
leukocyte activation |
|
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
|
GO:0045793 |
positive regulation of cell size |
|
GO:0045840 |
positive regulation of mitosis |
|
GO:0045987 |
positive regulation of smooth muscle contraction |
|
GO:0046887 |
positive regulation of hormone secretion |
|
GO:0046888 |
negative regulation of hormone secretion |
|
GO:0048016 |
inositol phosphate-mediated signaling |
|
GO:0048514 |
blood vessel morphogenesis |
|
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
|
GO:0051216 |
cartilage development |
|
GO:0051482 |
elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger |
|
GO:0051771 |
negative regulation of nitric-oxide synthase biosynthetic process |
|
GO:0051899 |
membrane depolarization |
|
GO:0060298 |
positive regulation of sarcomere organization |
|
GO:0060585 |
positive regulation of prostaglandin-endoperoxide synthase activity |
|
GO:0071347 |
cellular response to interleukin-1 |
|
GO:0071356 |
cellular response to tumor necrosis factor |
|
GO:0071445 |
cellular response to protein stimulus |
