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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG001355

Entrez Gene ID

1950

Official Gene Symbol

EGF

Synonyms

HOMG4|URG

Gene name

epidermal growth factor

Gene Type

protein-coding

Chromosome

4

Genomics Location

4q25

Known cancer genes

Yes

Protein products

cDNA FLJ60402, highly similar to Pro-epidermal growth factor

Uncharacterized protein

Uncharacterized protein

Pro-epidermal growth factor

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Hepatocellular carcinoma

Intrahepatic cholangiocarcinoma

Hepatocellular carcinoma

Database cross reference

HGNC:3229
MIM:131530
Ensembl:ENSG00000138798
HPRD:00578
RefSeq Genomic nucleotide accession:AC_000047
RefSeq Genomic nucleotide gi:89161206

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net OncoDB

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000186

activation of MAPKK activity

GO:0001525

angiogenesis

GO:0002576

platelet degranulation

GO:0005154

epidermal growth factor receptor binding

GO:0005509

calcium ion binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005625

soluble fraction

GO:0005886

plasma membrane

GO:0006260

DNA replication

GO:0007165

signal transduction

GO:0007173

epidermal growth factor receptor signaling pathway

GO:0007596

blood coagulation

GO:0008083

growth factor activity

GO:0008284

positive regulation of cell proliferation

GO:0016021

integral to membrane

GO:0021940

positive regulation of cerebellar granule cell precursor proliferation

GO:0030168

platelet activation

GO:0030297

transmembrane receptor protein tyrosine kinase activator activity

GO:0031093

platelet alpha granule lumen

GO:0035413

positive regulation of catenin import into nucleus

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

GO:0042327

positive regulation of phosphorylation

GO:0043406

positive regulation of MAP kinase activity

GO:0045741

positive regulation of epidermal growth factor receptor activity

GO:0045840

positive regulation of mitosis

GO:0048754

branching morphogenesis of a tube

GO:0050708

regulation of protein secretion

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

GO:0051048

negative regulation of secretion

GO:0060749

mammary gland alveolus development

GO:0090279

regulation of calcium ion import

GO:2000008

regulation of protein localization at cell surface